Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein

Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80–95% and 25–60% of individuals harbor gut microbial comm...

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Veröffentlicht in:	European journal of clinical nutrition Jg. 68; H. 4; S. 526 - 530
Hauptverfasser:	Frankenfeld, C L, Atkinson, C, Wähälä, K, Lampe, J W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.04.2014 Nature Publishing Group
Schlagworte:	631/443/319 692/698/2741/2135 692/699/1702/393 692/700/478/174 Adolescent Adult Adults Aged Aged, 80 and over Biological and medical sciences Body Mass Index Body size Body weight Body Weight - physiology Clinical Nutrition Confidence intervals Cross-Sectional Studies Daidzein Epidemiology Equol - biosynthesis Equol - urine Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology Genotype & phenotype Humans Internal Medicine Intestinal microflora Isoflavones Isoflavones - biosynthesis Isoflavones - metabolism Isoflavones - urine Male Medical sciences Medicine Medicine & Public Health Menopause Metabolic Diseases Metabolites Microbial activity Microbiomes Microbiota Microorganisms Middle Aged Nutrition research Obesity Obesity - epidemiology Obesity - microbiology original-article Overweight Overweight - epidemiology Overweight - microbiology Phenotype Phenotypes Physiological aspects Post-menopause Prevalence Public Health Risk factors Self Report Soy Foods - analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult United States Isoflavone Obesity Prevalence Digestive system Nutrition disorder Equol Gut Environment Metabolic diseases Daidzein Epidemiology Nutritional status
ISSN:	0954-3007, 1476-5640, 1476-5640
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Zusammenfassung:	Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80–95% and 25–60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. Subjects/methods: Adults aged 18–95 years ( n =297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. Results: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. Conclusions: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0954-3007 1476-5640 1476-5640
DOI:	10.1038/ejcn.2014.23