Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein

Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80–95% and 25–60% of individuals harbor gut microbial comm...

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Veröffentlicht in:European journal of clinical nutrition Jg. 68; H. 4; S. 526 - 530
Hauptverfasser: Frankenfeld, C L, Atkinson, C, Wähälä, K, Lampe, J W
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.04.2014
Nature Publishing Group
Schlagworte:
631/443/319
692/698/2741/2135
692/699/1702/393
692/700/478/174
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Biological and medical sciences
Body Mass Index
Body size
Body weight
Body Weight - physiology
Clinical Nutrition
Confidence intervals
Cross-Sectional Studies
Daidzein
Epidemiology
Equol - biosynthesis
Equol - urine
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - microbiology
Genotype & phenotype
Humans
Internal Medicine
Intestinal microflora
Isoflavones
Isoflavones - biosynthesis
Isoflavones - metabolism
Isoflavones - urine
Male
Medical sciences
Medicine
Medicine & Public Health
Menopause
Metabolic Diseases
Metabolites
Microbial activity
Microbiomes
Microbiota
Microorganisms
Middle Aged
Nutrition research
Obesity
Obesity - epidemiology
Obesity - microbiology
original-article
Overweight
Overweight - epidemiology
Overweight - microbiology
Phenotype
Phenotypes
Physiological aspects
Post-menopause
Prevalence
Public Health
Risk factors
Self Report
Soy Foods - analysis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
United States
Isoflavone
Obesity
Prevalence
Digestive system
Nutrition disorder
Equol
Gut
Environment
Metabolic diseases
Daidzein
Epidemiology
Nutritional status
ISSN:0954-3007, 1476-5640, 1476-5640
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Abstract Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80–95% and 25–60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. Subjects/methods: Adults aged 18–95 years ( n =297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. Results: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. Conclusions: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
AbstractList BACKGROUND/OBJECTIVES: Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. SUBJECTS/METHODS: Adults aged 18-95 years (n = 297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. RESULTS: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR) = 2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR = 1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. CONCLUSIONS: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations. European Journal of Clinical Nutrition (2014) 68, 526-530; doi: 10.1038/ejcn.2014.23; published online 26 February 2014
Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80–95% and 25–60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. Subjects/methods: Adults aged 18–95 years ( n =297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. Results: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. Conclusions: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
Background/ objectives: Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals.Subjects/ methods: Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. Results: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. Conclusions: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
Background/objectives:Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals.Subjects/methods:Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height.Results:There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers.Conclusions:Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations. [PUBLICATION ABSTRACT]
Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals.BACKGROUND/OBJECTIVESStudies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals.Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height.SUBJECTS/METHODSAdults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height.There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers.RESULTSThere were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers.Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.CONCLUSIONSResults from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.
Audience Professional
Academic
Author Atkinson, C
Frankenfeld, C L
Lampe, J W
Wähälä, K
AuthorAffiliation 2 Bristol Dental School, University of Bristol, Bristol, BS2 8AE, UK
3 Department of Chemistry, University of Helsinki, FIN-00014, Finland
4 Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
1 Department of Global and Community Health, George Mason University, Fairfax, VA, 22030, USA
AuthorAffiliation_xml – name: 3 Department of Chemistry, University of Helsinki, FIN-00014, Finland
– name: 4 Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
– name: 1 Department of Global and Community Health, George Mason University, Fairfax, VA, 22030, USA
– name: 2 Bristol Dental School, University of Bristol, Bristol, BS2 8AE, UK
Author_xml – sequence: 1
  givenname: C L
  orcidid: 0000-0002-2318-0791
  surname: Frankenfeld
  fullname: Frankenfeld, C L
  email: cfranken@gmu.edu
  organization: Department of Global and Community Health, George Mason University
– sequence: 2
  givenname: C
  surname: Atkinson
  fullname: Atkinson, C
  organization: Bristol Dental School, University of Bristol
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  surname: Wähälä
  fullname: Wähälä, K
  organization: Department of Chemistry, University of Helsinki, Helsinki, Finland
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  surname: Lampe
  fullname: Lampe, J W
  organization: Public Health Sciences, Fred Hutchinson Cancer Research Center
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ContentType Journal Article
Copyright Macmillan Publishers Limited 2014
2015 INIST-CNRS
COPYRIGHT 2014 Nature Publishing Group
Copyright Nature Publishing Group Apr 2014
Macmillan Publishers Limited 2014.
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– notice: 2015 INIST-CNRS
– notice: COPYRIGHT 2014 Nature Publishing Group
– notice: Copyright Nature Publishing Group Apr 2014
– notice: Macmillan Publishers Limited 2014.
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Issue 4
Keywords Isoflavone
Obesity
Prevalence
Digestive system
Nutrition disorder
Equol
Gut
Environment
Metabolic diseases
Daidzein
Epidemiology
Nutritional status
Language English
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SSID ssj0014772
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Snippet Background/objectives: Studies have observed associations between the gut microbiome and obesity. O -desmethylangolensin (ODMA) and equol are gut bacterial...
Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a...
BACKGROUND/OBJECTIVES: Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial...
Background/objectives:Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial...
Background/ objectives: Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial...
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SubjectTerms 631/443/319
692/698/2741/2135
692/699/1702/393
692/700/478/174
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Biological and medical sciences
Body Mass Index
Body size
Body weight
Body Weight - physiology
Clinical Nutrition
Confidence intervals
Cross-Sectional Studies
Daidzein
Epidemiology
Equol - biosynthesis
Equol - urine
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - microbiology
Genotype & phenotype
Humans
Internal Medicine
Intestinal microflora
Isoflavones
Isoflavones - biosynthesis
Isoflavones - metabolism
Isoflavones - urine
Male
Medical sciences
Medicine
Medicine & Public Health
Menopause
Metabolic Diseases
Metabolites
Microbial activity
Microbiomes
Microbiota
Microorganisms
Middle Aged
Nutrition research
Obesity
Obesity - epidemiology
Obesity - microbiology
original-article
Overweight
Overweight - epidemiology
Overweight - microbiology
Phenotype
Phenotypes
Physiological aspects
Post-menopause
Prevalence
Public Health
Risk factors
Self Report
Soy Foods - analysis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
Title Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein
URI https://link.springer.com/article/10.1038/ejcn.2014.23
https://www.ncbi.nlm.nih.gov/pubmed/24569543
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https://pubmed.ncbi.nlm.nih.gov/PMC4189015
Volume 68
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