TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary...

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Veröffentlicht in:	PLoS pathogens Jg. 17; H. 9; S. e1009941
Hauptverfasser:	Collins, Jeffrey M., Jones, Dean P., Sharma, Ashish, Khadka, Manoj, Liu, Ken H., Kempker, Russell R., Prideaux, Brendan, Maner-Smith, Kristal, Tukvadze, Nestani, Shah, N. Sarita, Brust, James C. M., Sékaly, Rafick-Pierre, Gandhi, Neel R., Blumberg, Henry M., Ortlund, Eric A., Ziegler, Thomas R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	San Francisco Public Library of Science 24.09.2021 Public Library of Science (PLoS)
Schlagworte:	Accumulation Arachidonic acid Asymptomatic Biology and Life Sciences Carboxylic acids Cellular signal transduction Chemotherapy Chromatography Correlation analysis COVID-19 Cytokines Dehydrogenases Development and progression Drug therapy Eicosanoids Fatty acids Health aspects HIV Human immunodeficiency virus IL-1β Infections Inflammation Intermediates Lipids Lung diseases Medicine and Health Sciences Metabolic response Metabolism Metabolites Metabolomics Multidrug resistance Phospholipase A2 Physiological aspects Plasma Pulmonary tuberculosis Signaling Tricarboxylic acid cycle Tuberculosis United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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