The support of human genetic evidence for approved drug indications

Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene products that are successful drug targets and genetic loci associated with the disease treated by the drug and predict that selecting genetica...

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Vydáno v:	Nature genetics Ročník 47; číslo 8; s. 856 - 860
Hlavní autoři:	Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, Cardon, Lon R, Whittaker, John C, Sanseau, Philippe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.08.2015 Nature Publishing Group
Témata:	631/154/1435 631/208/205 Agriculture analysis Animal Genetics and Genomics Biomedicine Cancer Research Chromosome Mapping Databases, Genetic - statistics & numerical data Drug Approval - statistics & numerical data Drug interactions Drug metabolism Drugs Gene Function Genes Genetic aspects Genetic Association Studies - statistics & numerical data Genetic Predisposition to Disease - genetics Genetic research Genetics Genetics, Medical - methods Genetics, Medical - statistics & numerical data Genome-Wide Association Study - statistics & numerical data Human Genetics Humans Innovations Linkage Disequilibrium Medical Subject Headings - utilization Molecular targeted therapy Molecular Targeted Therapy - statistics & numerical data Pharmacology Polymorphism, Single Nucleotide
ISSN:	1061-4036, 1546-1718
On-line přístup:	Získat plný text
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