Visualization of recombination-mediated damage bypass by template switching

A combination of two-dimensional gel electrophoresis and EM is used to isolate and characterize multiple template-switching intermediates generated in budding yeast during replication of damaged DNA. Template switching (TS) mediates damage bypass via a recombination-related mechanism involving PCNA...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 21; no. 10; pp. 884 - 892
Main Authors:	Giannattasio, Michele, Zwicky, Katharina, Follonier, Cindy, Foiani, Marco, Lopes, Massimo, Branzei, Dana
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2014 Nature Publishing Group
Subjects:	631/114 631/1647/2210 631/337/100 631/337/572 Biochemistry Biological Microscopy Brewer's yeast Cell division Chromatids Deoxyribonucleic acid DNA DNA Damage DNA Polymerase III - genetics DNA Repair DNA Replication - genetics DNA, Cruciform DNA, Fungal - biosynthesis DNA, Fungal - genetics Electrophoresis Genetic aspects Genetic recombination Genetic research Genetics Life Sciences Membrane Biology Molecular biology Proliferating Cell Nuclear Antigen - metabolism Properties Protein Structure Quantitative trait loci Recombination, Genetic Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Templates, Genetic Toxicity Ubiquitination Yeast
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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