Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of nonalcoholic steatohepatitis (NASH), but the exact mechanisms are not clear. Mice with disruption of the gene (F11r) encoding junctional adhesion molecule A (JAM-A) have defe...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) Jg. 151; H. 4; S. 733
Hauptverfasser:	Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S, Thorn, Natalie E, Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S, Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B, Nusrat, Asma, Parkos, Charles A, Anania, Frank A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2016
Schlagworte:	Animals Cell Adhesion Molecules - deficiency Cholesterol Diet, High-Fat - adverse effects Diet, High-Fat - methods Dietary Carbohydrates Disease Models, Animal Dysbiosis - complications Dysbiosis - genetics Fructose Gastrointestinal Microbiome - genetics Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Liver - pathology Male Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - microbiology Non-alcoholic Fatty Liver Disease - pathology Permeability Receptors, Cell Surface - deficiency Reverse Transcriptase Polymerase Chain Reaction Bacterial Translocation Claudin-4 Occludin
ISSN:	1528-0012, 1528-0012
Online-Zugang:	Weitere Angaben
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