Turning off the tap: stopping tuberculosis transmission through active case-finding and prompt effective treatment

To halt the global tuberculosis epidemic, transmission must be stopped to prevent new infections and new cases. Identification of individuals with tuberculosis and prompt initiation of effective treatment to rapidly render them non-infectious is crucial to this task. However, in settings of high tub...

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Veröffentlicht in:The Lancet (British edition) Jg. 386; H. 10010; S. 2334 - 2343
Hauptverfasser: Yuen, Courtney M, Amanullah, Farhana, Dharmadhikari, Ashwin, Nardell, Edward A, Seddon, James A, Vasilyeva, Irina, Zhao, Yanlin, Keshavjee, Salmaan, Becerra, Mercedes C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 05.12.2015
Elsevier Limited
Schlagworte:
Cross Infection - prevention & control
Cross Infection - transmission
Disease control
Disease transmission
Early Diagnosis
Epidemics
Humans
Internal Medicine
Mass Screening - organization & administration
Medical treatment
Mycobacterium
Secondary Prevention - methods
Translational Medical Research - methods
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - transmission
ISSN:0140-6736, 1474-547X, 1474-547X
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Zusammenfassung:To halt the global tuberculosis epidemic, transmission must be stopped to prevent new infections and new cases. Identification of individuals with tuberculosis and prompt initiation of effective treatment to rapidly render them non-infectious is crucial to this task. However, in settings of high tuberculosis burden, active case-finding is often not implemented, resulting in long delays in diagnosis and treatment. A range of strategies to find cases and ensure prompt and correct treatment have been shown to be effective in high tuberculosis-burden settings. The population-level effect of targeted active case-finding on reducing tuberculosis incidence has been shown by studies and projected by mathematical modelling. The inclusion of targeted active case-finding in a comprehensive epidemic-control strategy for tuberculosis should contribute substantially to a decrease in tuberculosis incidence.
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Joint senior authors
ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(15)00322-0