Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variatio...

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Bibliographic Details
Published in:	BMC genomics Vol. 21; no. 1; pp. 228 - 14
Main Authors:	Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 14.03.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	African Americans Animal Genetics and Genomics Biomedical and Life Sciences Black or African American - genetics Blood cell traits Combined-phenotype analysis Diversity Erythrocytes Erythrocytes - metabolism Female Genes Genetic aspects Genetic research Genetics, Population Genome-wide association studies Genome-Wide Association Study - methods Genomics GWAS Hispanic or Latino - genetics Human and rodent genomics Humans Identification and classification Life Sciences Male Microarrays Microbial Genetics and Genomics Minority & ethnic groups Multi-ethnic Multifactorial Inheritance Phenotype Phenotypes Plant Genetics and Genomics Pleiotropy Polymorphism, Single Nucleotide Power (Philosophy) Proteomics Quantitative trait loci Quantitative Trait, Heritable Red blood cells Research Article Sequence Analysis, DNA Single nucleotide polymorphisms United States - ethnology White People - genetics United States Multi-ethnic Combined-phenotype analysis Pleiotropy GWAS Blood cell traits Diversity
ISSN:	1471-2164, 1471-2164
Online Access:	Get full text
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