Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder

Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and restricted and repetitive behaviors. However, the symptoms are heterogeneous among patients an...

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Vydáno v:Behavioral and brain functions Ročník 12; číslo 1; s. 3
Hlavní autoři: Kim, Hyopil, Lim, Chae-Seok, Kaang, Bong-Kiun
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 20.01.2016
Springer Nature B.V
Témata:
Animals
Autism Spectrum Disorder - physiopathology
Autism Spectrum Disorder - psychology
Basal Ganglia Diseases - physiopathology
Basal Ganglia Diseases - psychology
Behavior - physiology
Behavioral Therapy
Biomedical and Life Sciences
Biomedicine
Compulsive Behavior - physiopathology
Compulsive Behavior - psychology
Disease Models, Animal
Humans
Mice
Neurobiology of brain disorders
Neurology
Neurosciences
Psychiatry
Review
Cortico-basal ganglia-thalamic circuits
Autism spectrum disorder
ASD mouse models
Repetitive behaviors
ISSN:1744-9081, 1744-9081
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Shrnutí:Autism spectrum disorder (ASD) refers to a broad spectrum of neurodevelopmental disorders characterized by three central behavioral symptoms: impaired social interaction, impaired social communication, and restricted and repetitive behaviors. However, the symptoms are heterogeneous among patients and a number of ASD mouse models have been generated containing mutations that mimic the mutations found in human patients with ASD. Each mouse model was found to display a unique set of repetitive behaviors. In this review, we summarize the repetitive behaviors of the ASD mouse models and variations found in their neural mechanisms including molecular and electrophysiological features. We also propose potential neuronal mechanisms underlying these repetitive behaviors, focusing on the role of the cortico-basal ganglia-thalamic circuits and brain regions associated with both social and repetitive behaviors. Further understanding of molecular and circuitry mechanisms of the repetitive behaviors associated with ASD is necessary to aid the development of effective treatments for these disorders.
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ISSN:1744-9081
1744-9081
DOI:10.1186/s12993-016-0087-y