NGmerge: merging paired-end reads via novel empirically-derived models of sequencing errors

Background Advances in Illumina DNA sequencing technology have produced longer paired-end reads that increasingly have sequence overlaps. These reads can be merged into a single read that spans the full length of the original DNA fragment, allowing for error correction and accurate determination of...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 19; no. 1; pp. 536 - 9
Main Author:	Gaspar, John M.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 20.12.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Algorithms Analysis Bioinformatics Biomedical and Life Sciences Cancer Computational Biology/Bioinformatics Computer Appl. in Life Sciences Deoxyribonucleic acid DNA DNA sequencing Empirical analysis Error correction Error correction & detection Genomes High-Throughput Nucleotide Sequencing - methods High-throughput sequencing Humans Illumina paired-end sequencing Life Sciences Methodology Methodology Article Microarrays Nucleotide sequence Open source software Quality Read merging Sequence analysis (methods) Sequence Analysis, DNA - methods sequencing errors; quality scores; PhiX Source programs High-throughput sequencing Illumina paired-end sequencing Read merging sequencing errors; quality scores; PhiX
ISSN:	1471-2105, 1471-2105
Online Access:	Get full text
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