Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

[Display omitted] •YAP is activated by myocardial infarction or neuroendocrine stimulation in cardiac fibroblasts.•Active YAP promotes TEA domain transcription factor-1–mediated transcription of myocardin-related transcription factor A to facilitate cardiac myofibroblast differentiation and extracel...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	JACC. Basic to translational science Ročník 5; číslo 9; s. 931 - 945
Hlavní autori:	Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.09.2020 Elsevier
Predmet:	cardiac fibrosis Cardiovascular heart failure Hippo signaling myocardial infarction Preclinical Research YAP heart failure Hippo signaling NRCF MRTF-A SMA myocardial infarction Mkl1 YAP mRNA TGF TEAD cardiac fibrosis PE MCM PDGFR MI AngII myocardin-related transcription factor A neonatal rat cardiac fibroblast Mer-Cre-Mer phenylephrine platelet-derived growth factor receptor messenger ribonucleic acid yes-associated protein megakaryoblastic leukemia 1 TEA domain transcription factor angiotensin II transforming growth factor smooth muscle actin NRCF, neonatal rat cardiac fibroblast MRTF-A, myocardin-related transcription factor A Mkl1, megakaryoblastic leukemia 1 YAP, yes-associated protein MI, myocardial infarction PDGFR, platelet-derived growth factor receptor SMA, smooth muscle actin TGF, transforming growth factor MCM, Mer-Cre-Mer PE, phenylephrine AngII, angiotensin II TEAD, TEA domain transcription factor mRNA, messenger ribonucleic acid
ISSN:	2452-302X, 2452-302X
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!