Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environment...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 25; no. 7; pp. 1430 - 1446
Main Authors:	Coleman, Jonathan R I, Peyrot, Wouter J, Purves, Kirstin L, Davis, Katrina A S, Rayner, Christopher, Choi, Shing Wan, Hübel, Christopher, Gaspar, Héléna A, Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M, Choi, Karmel W, Dunn, Erin C, Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J, Lewis, Cathryn M, O'Reilly, Paul F, McIntosh, Andrew M, Smith, Daniel J, Wray, Naomi R, Hotopf, Matthew, Eley, Thalia C, Breen, Gerome
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.07.2020
Subjects:	Adult Aged Biobanks Body composition Databases, Factual Depressive Disorder, Major - epidemiology Depressive Disorder, Major - genetics Female Gene-Environment Interaction Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes Heritability Humans Male Mental depression Middle Aged Minors Psychological Trauma - epidemiology Risk factors Self Report Sex offenders Single-nucleotide polymorphism Trauma United Kingdom - epidemiology Waist Circumference United Kingdom United Kingdom > UK
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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