Intragenic sequences in the trophectoderm harbour the greatest proportion of methylation errors in day 17 bovine conceptuses generated using assisted reproductive technologies

Background Assisted reproductive technologies (ART) are widely used to treat fertility issues in humans and for the production of embryos in mammalian livestock. The use of these techniques, however, is not without consequence as they are often associated with inauspicious pre- and postnatal outcome...

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Bibliographic Details
Published in:	BMC genomics Vol. 19; no. 1; pp. 438 - 15
Main Authors:	O’Doherty, Alan M., McGettigan, Paul, Irwin, Rachelle E., Magee, David A., Gagne, Dominic, Fournier, Eric, Al-Naib, Abdullah, Sirard, Marc-André, Walsh, Colum P., Robert, Claude, Fair, Trudee
Format:	Journal Article
Language:	English
Published:	London BioMed Central 05.06.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Animal Genetics and Genomics Animals Assisted reproduction technologies (ART) Bioinformatics Biomedical and Life Sciences Bovidae Bovine Cancer Cattle Cattle - embryology Cattle - genetics Cell culture Cell morphology Cytology Deoxyribonucleic acid DNA DNA Methylation DNA probes Embryo Embryonic development Embryos Epigenetics Fertility Fertilization Fetuses Gene body Gene expression Genetic aspects Genetic engineering Genetic Loci - genetics Genomes Genomics In vitro fertilization Influence Intergenic DNA Life Sciences Livestock Loci Microarrays Microbial Genetics and Genomics Morphology Multivariate analysis Non-human and non-rodent vertebrate genomics Offspring Ovulation Physiological aspects Physiology Plant Genetics and Genomics Premature birth Proteomics Reproductive Techniques, Assisted Reproductive technologies Reproductive technology Research Article Trophectoderm Trophoblasts - metabolism Assisted reproduction technologies (ART) Embryo Reproduction Gene body Bovine Epigenetics DNA methylation Development Genomic imprinting
ISSN:	1471-2164, 1471-2164
Online Access:	Get full text
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