HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant

Chronic infection with hepatitis B virus (HBV) progresses through different phases. The first, called the immune-tolerant phase, has been associated with a lack of disease activity. We examined HBV-DNA integration, clonal hepatocyte expansion, HBV antigen expression, and HBV-specific immune response...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 151; no. 5; p. 986
Main Authors:	Mason, William S, Gill, Upkar S, Litwin, Samuel, Zhou, Yan, Peri, Suraj, Pop, Oltin, Hong, Michelle L W, Naik, Sandhia, Quaglia, Alberto, Bertoletti, Antonio, Kennedy, Patrick T F
Format:	Journal Article
Language:	English
Published:	United States 01.11.2016
Subjects:	Adolescent Adult Biomarkers - metabolism Case-Control Studies DNA, Viral - immunology Female Hepatitis B e Antigens - metabolism Hepatitis B Surface Antigens - metabolism Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Hepatocytes - immunology Hepatocytes - virology Humans Immune Tolerance Male Matched-Pair Analysis Virus Integration - immunology Young Adult Hepatocyte Proliferation HBsAg Antiviral Immunity HBV Replication
ISSN:	1528-0012, 1528-0012
Online Access:	Get more information
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