Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

Background The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neoplas...

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Bibliographic Details
Published in:	BMC medical genomics Vol. 9; no. 1; pp. 64 - 10
Main Authors:	Wei, Lei, Papanicolau-Sengos, Antonios, Liu, Song, Wang, Jianmin, Conroy, Jeffrey M., Glenn, Sean T., Brese, Elizabeth, Hu, Qiang, Miles, Kiersten Marie, Burgher, Blake, Qin, Maochun, Head, Karen, Omilian, Angela R., Bshara, Wiam, Krolewski, John, Trump, Donald L., Johnson, Candace S., Morrison, Carl D.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.10.2016 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adjacent normal tissues Bioinformatic and algorithmical studies Biomedical and Life Sciences Biomedicine DNA Mutational Analysis DNA sequencing Gene Expression Gene mutations Genome, Human - genetics High-Throughput Nucleotide Sequencing Human Genetics Humans Methods Microarrays Mutation Neoplasms - genetics Nucleotide sequencing Physiological aspects Research Article Somatic mutations Tumor contamination United States Somatic mutations Tumor contamination Adjacent normal tissues
ISSN:	1755-8794, 1755-8794
Online Access:	Get full text
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