Advancing functional connectivity research from association to causation

Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature neuroscience Ročník 22; číslo 11; s. 1751 - 1760
Hlavní autori:	Reid, Andrew T, Headley, Drew B, Mill, Ravi D, Sanchez-Romero, Ruben, Uddin, Lucina Q, Marinazzo, Daniele, Lurie, Daniel J, Valdés-Sosa, Pedro A, Hanson, Stephen José, Biswal, Bharat B, Calhoun, Vince, Poldrack, Russell A, Cole, Michael W
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Nature Publishing Group 01.11.2019
Predmet:	Animals Brain Brain - physiology Brain research Causation Cognition Correlation analysis Functional Neuroimaging - methods Humans Models, Neurological Neural networks Neural Pathways - physiology Statistics Validation Studies as Topic
ISSN:	1097-6256, 1546-1726, 1546-1726
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods ('effective connectivity') is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures.
AbstractList	Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series—functional connectivity (FC) methods—are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods (‘effective connectivity’) is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures. Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods ('effective connectivity') is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures.Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods ('effective connectivity') is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures.
Author	Hanson, Stephen José Cole, Michael W Poldrack, Russell A Sanchez-Romero, Ruben Valdés-Sosa, Pedro A Reid, Andrew T Lurie, Daniel J Uddin, Lucina Q Marinazzo, Daniele Mill, Ravi D Biswal, Bharat B Calhoun, Vince Headley, Drew B
Author_xml	– sequence: 1 givenname: Andrew T surname: Reid fullname: Reid, Andrew T organization: School of Psychology, University of Nottingham, Nottingham, UK – sequence: 2 givenname: Drew B surname: Headley fullname: Headley, Drew B organization: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA – sequence: 3 givenname: Ravi D surname: Mill fullname: Mill, Ravi D organization: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA – sequence: 4 givenname: Ruben surname: Sanchez-Romero fullname: Sanchez-Romero, Ruben organization: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA – sequence: 5 givenname: Lucina Q surname: Uddin fullname: Uddin, Lucina Q organization: Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, USA – sequence: 6 givenname: Daniele surname: Marinazzo fullname: Marinazzo, Daniele organization: Department of Data Analysis, Ghent University, Ghent, Belgium – sequence: 7 givenname: Daniel J surname: Lurie fullname: Lurie, Daniel J organization: Department of Psychology, University of California, Berkeley, Berkeley, CA, USA – sequence: 8 givenname: Pedro A surname: Valdés-Sosa fullname: Valdés-Sosa, Pedro A organization: Cuban Neuroscience Center, La Habana, Cuba – sequence: 9 givenname: Stephen José surname: Hanson fullname: Hanson, Stephen José organization: RUBIC & Department of Psychology, Rutgers University, Newark, NJ, USA – sequence: 10 givenname: Bharat B surname: Biswal fullname: Biswal, Bharat B organization: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA – sequence: 11 givenname: Vince orcidid: 0000-0001-9058-0747 surname: Calhoun fullname: Calhoun, Vince organization: Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University], Atlanta, GA, USA – sequence: 12 givenname: Russell A orcidid: 0000-0001-6755-0259 surname: Poldrack fullname: Poldrack, Russell A organization: Department of Psychology, Stanford University, Stanford, CA, USA – sequence: 13 givenname: Michael W orcidid: 0000-0003-4329-438X surname: Cole fullname: Cole, Michael W email: mwcole@mwcole.net organization: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA. mwcole@mwcole.net
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31611705$$D View this record in MEDLINE/PubMed
BookMark	eNpd0E1LAzEQBuAgFfuhP8CLLHjxEs1sPmZzLEWtUPCi5yXNJrplm9TNbqH_3rXWi6eZFx4G3pmSUYjBEXIN7B4YLx6SAKk5ZaApk8CoOCMTkEJRwFyNhp1ppCqXakymKW0YYygLfUHGHBQAMjkhy3m1N8HW4SPzfbBdHYNpMhtDcEPY190ha11yprWfmW_jNjMpRVubH5h1MbOmT8dwSc69aZK7Os0ZeX96fFss6er1-WUxX1GrOHZU5hwtV6woKuXXwJwQ0qsKZSWEH4pwbw0YLRU6AZXxwqEDr1BrdEVhgc_I3e_dXRu_epe6clsn65rGBBf7VOacSdSS53qgt__oJvbt0O-oNKLQDAd1c1L9euuqctfWW9Meyr8f8W_YgGor
CitedBy_id	crossref_primary_10_3390_e22090917 crossref_primary_10_1038_s41583_024_00881_3 crossref_primary_10_1016_j_jsxm_2022_03_217 crossref_primary_10_1038_s41562_024_01826_7 crossref_primary_10_1162_netn_a_00206 crossref_primary_10_1016_j_neuroimage_2022_119400 crossref_primary_10_1016_j_physrep_2023_10_005 crossref_primary_10_1016_j_isci_2024_111585 crossref_primary_10_1162_netn_a_00323 crossref_primary_10_7554_eLife_92938_3 crossref_primary_10_1162_netn_a_00325 crossref_primary_10_1016_j_nicl_2021_102663 crossref_primary_10_1162_netn_a_00321 crossref_primary_10_1016_j_conb_2020_09_009 crossref_primary_10_1016_j_jneumeth_2022_109720 crossref_primary_10_1093_cercor_bhab526 crossref_primary_10_1016_j_plrev_2024_04_012 crossref_primary_10_3389_fnagi_2025_1536658 crossref_primary_10_1016_j_neurobiolaging_2020_07_029 crossref_primary_10_1038_s42003_021_02002_7 crossref_primary_10_1038_s41467_020_18997_2 crossref_primary_10_1038_s41597_020_00595_y crossref_primary_10_1111_ejn_15889 crossref_primary_10_1016_j_engappai_2024_109347 crossref_primary_10_1098_rsta_2020_0263 crossref_primary_10_1016_j_nicl_2024_103630 crossref_primary_10_3389_fnsys_2022_817962 crossref_primary_10_3389_fnins_2021_652841 crossref_primary_10_1016_j_neuroimage_2021_118722 crossref_primary_10_1016_j_neuroimage_2021_118288 crossref_primary_10_1073_pnas_2219693120 crossref_primary_10_7554_eLife_92938 crossref_primary_10_1038_s41593_020_00719_y crossref_primary_10_1002_aur_2488 crossref_primary_10_1016_j_inffus_2021_03_009 crossref_primary_10_1016_j_bandc_2024_106221 crossref_primary_10_1162_netn_a_00429 crossref_primary_10_3390_brainsci12121649 crossref_primary_10_1016_j_neuroimage_2023_120091 crossref_primary_10_1109_TMI_2020_2990371 crossref_primary_10_1162_netn_a_00302 crossref_primary_10_3389_fnhum_2022_870091 crossref_primary_10_1007_s00429_022_02570_2 crossref_primary_10_1016_j_tics_2019_10_005 crossref_primary_10_3390_brainsci10010008 crossref_primary_10_1162_netn_a_00267 crossref_primary_10_1007_s00521_023_09047_1 crossref_primary_10_1016_j_neuroimage_2020_117205 crossref_primary_10_1162_netn_a_00384 crossref_primary_10_3389_fnins_2020_602584 crossref_primary_10_1007_s00429_021_02362_0 crossref_primary_10_1109_ACCESS_2025_3529179 crossref_primary_10_1016_j_neuroimage_2021_118533 crossref_primary_10_1038_s41598_023_38513_y crossref_primary_10_1016_j_conb_2020_10_004 crossref_primary_10_1093_cercor_bhaa334 crossref_primary_10_1002_hbm_25607 crossref_primary_10_1007_s00221_021_06036_5 crossref_primary_10_1038_s41467_024_48781_5 crossref_primary_10_1109_JBHI_2022_3201111 crossref_primary_10_1038_s41593_020_00726_z crossref_primary_10_1523_JNEUROSCI_1713_20_2021 crossref_primary_10_1038_s43588_022_00282_5 crossref_primary_10_1162_netn_a_00259 crossref_primary_10_3389_fncom_2023_1251301 crossref_primary_10_1016_j_neuroimage_2020_117556 crossref_primary_10_1093_psyrad_kkad007 crossref_primary_10_1162_netn_a_00252 crossref_primary_10_3390_brainsci11040487 crossref_primary_10_1016_j_neuroimage_2021_118149 crossref_primary_10_1016_j_tics_2022_09_021 crossref_primary_10_1162_jocn_a_02127 crossref_primary_10_1016_j_chaos_2024_115567 crossref_primary_10_1017_S0033291721001513 crossref_primary_10_3389_fncom_2020_00045 crossref_primary_10_1016_j_jad_2023_05_025 crossref_primary_10_1523_ENEURO_0403_24_2025 crossref_primary_10_3389_fnagi_2022_862107 crossref_primary_10_1109_ACCESS_2023_3244066 crossref_primary_10_1002_hbm_26044 crossref_primary_10_1016_j_ijpsycho_2021_12_008 crossref_primary_10_1016_j_procs_2023_01_073 crossref_primary_10_1016_j_tics_2020_03_006 crossref_primary_10_1162_netn_a_00402 crossref_primary_10_3390_brainsci13040631 crossref_primary_10_3389_fnint_2022_928978 crossref_primary_10_1073_pnas_2306279120 crossref_primary_10_1002_wcs_1553 crossref_primary_10_1038_s41593_020_00709_0 crossref_primary_10_1016_j_biopsych_2020_05_010 crossref_primary_10_1145_3480971 crossref_primary_10_1146_annurev_statistics_040120_010930 crossref_primary_10_1007_s00429_024_02796_2 crossref_primary_10_1103_Physics_18_71 crossref_primary_10_1371_journal_pcbi_1012870 crossref_primary_10_1016_j_neuroimage_2020_117141 crossref_primary_10_1007_s11222_023_10330_3 crossref_primary_10_1038_s41593_022_01070_0 crossref_primary_10_3389_fninf_2020_581897 crossref_primary_10_1016_j_jad_2023_05_074 crossref_primary_10_3390_brainsci12030346 crossref_primary_10_1093_cercor_bhab047 crossref_primary_10_3389_fnagi_2022_911513 crossref_primary_10_1109_JIOT_2023_3312407 crossref_primary_10_1162_netn_a_00239 crossref_primary_10_3390_e22060617 crossref_primary_10_1007_s10548_019_00744_6 crossref_primary_10_1016_j_tics_2022_11_015 crossref_primary_10_1038_s41380_024_02767_3 crossref_primary_10_1162_netn_a_00116 crossref_primary_10_1038_s41467_023_41024_z crossref_primary_10_1038_s41467_023_38626_y crossref_primary_10_1162_netn_a_00231 crossref_primary_10_1371_journal_pbio_3001686 crossref_primary_10_1093_psyrad_kkab003 crossref_primary_10_1109_TCDS_2022_3175538 crossref_primary_10_1073_pnas_2117234119 crossref_primary_10_3389_fpsyg_2022_915260 crossref_primary_10_1109_TNNLS_2024_3514182 crossref_primary_10_1371_journal_pcbi_1012507 crossref_primary_10_1038_s41593_022_01118_1 crossref_primary_10_1038_s42003_024_06731_3 crossref_primary_10_1088_1741_2552_ac9d66 crossref_primary_10_1016_j_neuroimage_2023_120213 crossref_primary_10_1109_TNSRE_2024_3360137 crossref_primary_10_1016_j_neuroimage_2022_119347 crossref_primary_10_1371_journal_pcbi_1011571 crossref_primary_10_1016_j_compbiomed_2025_109898 crossref_primary_10_1016_j_plrev_2024_05_006 crossref_primary_10_1016_j_bspc_2025_108336 crossref_primary_10_1038_s41583_023_00778_7 crossref_primary_10_1162_jocn_a_01580 crossref_primary_10_1162_jocn_a_01623 crossref_primary_10_3390_biology9080236 crossref_primary_10_1007_s11357_022_00686_1 crossref_primary_10_1016_j_neuron_2022_05_011 crossref_primary_10_1016_j_neuropsychologia_2023_108783 crossref_primary_10_1038_s41592_025_02704_4 crossref_primary_10_3389_fnins_2023_978527 crossref_primary_10_1162_imag_a_00026 crossref_primary_10_1038_s42003_024_07160_y crossref_primary_10_1371_journal_pcbi_1012934 crossref_primary_10_3390_e23121622 crossref_primary_10_1002_hbm_26331 crossref_primary_10_3389_fneur_2021_651663 crossref_primary_10_1016_j_bspc_2024_107054 crossref_primary_10_1016_j_neuroimage_2022_119451 crossref_primary_10_7554_eLife_79559 crossref_primary_10_1002_jbio_202200014 crossref_primary_10_1016_j_neuroimage_2022_119211 crossref_primary_10_3390_e24050735 crossref_primary_10_1007_s10548_019_00749_1 crossref_primary_10_1162_netn_a_00218 crossref_primary_10_1016_j_concog_2020_103021 crossref_primary_10_1016_j_jad_2025_02_076 crossref_primary_10_1016_j_ynirp_2025_100255 crossref_primary_10_3390_e26070540 crossref_primary_10_1371_journal_pcbi_1012130 crossref_primary_10_1016_j_neuroimage_2025_121195 crossref_primary_10_1109_TMI_2021_3110829 crossref_primary_10_1007_s11571_022_09863_6 crossref_primary_10_1109_TII_2024_3423311 crossref_primary_10_1162_jocn_a_01591 crossref_primary_10_1186_s12888_020_02831_6 crossref_primary_10_1016_j_pscychresns_2024_111945 crossref_primary_10_1109_TNSRE_2024_3373335 crossref_primary_10_1016_j_neuroimage_2021_118466 crossref_primary_10_1038_s41583_022_00583_8 crossref_primary_10_1038_s41598_021_90222_6 crossref_primary_10_1016_j_isci_2024_110628 crossref_primary_10_3389_fnins_2024_1237245 crossref_primary_10_1016_j_neuroimage_2021_118069 crossref_primary_10_1089_brain_2024_0056 crossref_primary_10_1162_imag_a_00553
ContentType	Journal Article
Copyright	Copyright Nature Publishing Group Nov 2019
Copyright_xml	– notice: Copyright Nature Publishing Group Nov 2019
DBID	CGR CUY CVF ECM EIF NPM 3V. 7QG 7QP 7QR 7TK 7TM 7U7 7U9 7X7 7XB 88E 88G 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M2M M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U RC3 7X8
DOI	10.1038/s41593-019-0510-4
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Toxicology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest : Biological Science Collection journals [unlimited simultaneous users] ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic Genetics Abstracts MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest Central Basic Toxicology Abstracts ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest One Psychology MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Statistics
EISSN	1546-1726
EndPage	1760
ExternalDocumentID	31611705
Genre	Research Support, U.S. Gov't, Non-P.H.S Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIMH NIH HHS grantid: R01 MH109520 – fundername: NIGMS NIH HHS grantid: P20 GM103472 – fundername: NIMH NIH HHS grantid: R01 MH107549 – fundername: NIA NIH HHS grantid: R01 AG055556 – fundername: NINDS NIH HHS grantid: F31 NS108665 – fundername: NIBIB NIH HHS grantid: R01 EB020407
GroupedDBID	--- -DZ .55 .GJ 0R~ 123 29M 2FS 36B 39C 4.4 53G 5RE 70F 7X7 85S 88E 8AO 8FI 8FJ 8R4 8R5 AARCD AAYZH ABAWZ ABDBF ABFSG ABIVO ABJNI ABLJU ABUWG ACBWK ACGFS ACIWK ACNCT ACPRK ACSTC ACUHS ADBBV ADXHL AENEX AETEA AEZWR AFANA AFBBN AFHIU AFKRA AFRAH AFSHS AGAYW AHBCP AHMBA AHOSX AHSBF AHWEU AIBTJ AIXLP ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ALPWD ARMCB ASPBG ATHPR AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CGR CS3 CUY CVF D0L DB5 DU5 DWQXO EAD EAP EBC EBD EBS ECM EE. EIF EJD EMB EMK EMOBN EPL EPS ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR IPY ISR ITC M1P M2M M7P MVM N9A NFIDA NNMJJ NPM O9- ODYON P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PSYQQ Q2X RNS RNT RNTTT SHXYY SIXXV SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M XJT YNT YQT ZGI ~8M 3V. 7QG 7QP 7QR 7TK 7TM 7U7 7U9 7XB 8FD 8FE 8FH 8FK AGSTI C1K FR3 H94 K9. LK8 P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 PUEGO
ID	FETCH-LOGICAL-c637t-5237c36088d6fb10e445f6d75d44f0193fca1a9567e41daf4e7e1f67997e88c13
IEDL.DBID	M7P
ISICitedReferencesCount	197
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000493396600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1097-6256 1546-1726
IngestDate	Thu Sep 04 20:37:05 EDT 2025 Mon Oct 06 18:35:31 EDT 2025 Mon Jul 21 06:00:00 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	11
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c637t-5237c36088d6fb10e445f6d75d44f0193fca1a9567e41daf4e7e1f67997e88c13
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 content type line 23
ORCID	0000-0001-6755-0259 0000-0001-9058-0747 0000-0003-4329-438X
OpenAccessLink	https://nottingham-repository.worktribe.com/output/3736595
PMID	31611705
PQID	2309774907
PQPubID	44706
PageCount	10
ParticipantIDs	proquest_miscellaneous_2305795329 proquest_journals_2309774907 pubmed_primary_31611705
PublicationCentury	2000
PublicationDate	2019-11-01
PublicationDateYYYYMMDD	2019-11-01
PublicationDate_xml	– month: 11 year: 2019 text: 2019-11-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: New York
PublicationTitle	Nature neuroscience
PublicationTitleAlternate	Nat Neurosci
PublicationYear	2019
Publisher	Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group
SSID	ssj0007589
Score	2.6759193
SecondaryResourceType	review_article
Snippet	Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function....
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1751
SubjectTerms	Animals Brain Brain - physiology Brain research Causation Cognition Correlation analysis Functional Neuroimaging - methods Humans Models, Neurological Neural networks Neural Pathways - physiology Statistics Validation Studies as Topic
Title	Advancing functional connectivity research from association to causation
URI	https://www.ncbi.nlm.nih.gov/pubmed/31611705 https://www.proquest.com/docview/2309774907 https://www.proquest.com/docview/2305795329
Volume	22
WOSCitedRecordID	wos000493396600004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB58Hbz4aH1Ua1lBvAWb7iabPYlKpZeWIgq9lWQzixeTalvBf-_MJq0nvXgJhIQlzE5mvnnsfABX0jKjbcYz9rs2UGhkkEmXB12TZ9pqhV1MPNmEHo2SycSM64TbvG6rXNlEb6jz0nKO_IagMkMViuVuZ-8Bs0ZxdbWm0NiEbZ6SIH3r3nhtiQkLG1_tNDognB-vqpoyuZmT4-LONT7CQ2oZqN8Rpvc0j_v__cYD2KsxprirlOIQNrBoQPOuoPj67UtcC9_16dPpDdhltFkNa27CwHMsW_Jmgv1dlSYUlnthbMUyIerhQK-Cz6WI9GdzxaIUNl1WzUFH8PLYf34YBDXVQmBjqRccjmorYzI5eeyysItKRS7OdZQr5UhI0tk0TCmW0qjCPHUKNYYu1sZoTBIbymPYKsoCT0FE6LIotgolGpU6azBJKYhEXspQdNiC9kp40_p_mU9_JNeCy_Vj0nQuX6QFlkv_TqRNJHumBSfVBk1n1UiOqSTgyoOBzv5e_Bx2e7zl_ixhG7YWH0u8gB37SYL-6MCmnmh_TTqwfd8fjZ_obtgbdrxa0XU0Hn4DdiTSng
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1NT9wwEB0BRYJLaaHAFtoaifYWsYmdOD5UCNGiRbArDlTiFhxnLC4kwO5S8af6GzvjbOAENw6cE1mKPZ55L_PxAHalY0Xbkmfs912k0MiolL6K-qYqtdMK-5gHsQk9GuUXF-ZsDv51vTBcVtn5xOCoq8bxP_I9gsoMVYjL7d_cRqwaxdnVTkKjNYsTfPhLlG388_gXne_3JDn6fX44iGaqApHLpJ4w89JOZnS7qsyXcR-VSn1W6bRSyhPgkd7Z2BJt0KjiynqFGmOfaWM05rmLJa07D-8UMSGWihgmw0fPT9jbhOyq0RHxiqzLosp8b0yBkivluGWIrkGknke0IbIdrby1PfkA72cYWhy0Rv8R5rBehbWD2k6a6wfxQ4Sq1pAuWIVlRtPtMOo1GAQNaUfRWnA8b3-DCse1Pq5V0RCz4UdXgvtuhH0yXjFphLPTtvjpE_x5lQ9ch4W6qXETRIq-TDOnUKJR1juDuSWSjLyUIfbbg-3usIqZPxgXTyfVg53Hx3STOT1ja2ym4Z1Um1QmpgcbrUEUN-3IkUISMOfBR59fXvwbLA3Oh6fF6fHoZAuWEza30De5DQuTuyl-gUV3T5t-9zUYroDL17aK_7_lKSA
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1NT9wwEB1RWlVcoHwUttDiSsAt2s3aieNDhVDpCkS12kORuAXHGYtLE2B3Qfw1fh0zTgIneuPQcyJLsd943mQ-HsCedKxoW_CM_YGLFBoZFdKX0cCUhXZa4QCzIDahx-Ps4sJMFuCx64XhssruTgwXdVk7_kfeJ6rMVIViub5vyyImx6PD65uIFaQ409rJaTQQOcOHewrfpj9Oj-ms94fD0a8_P0-iVmEgcqnUM47CtJMpWVqZ-iIeoFKJT0udlEp5Ij_SOxtbCiE0qri0XqHG2KfaGI1Z5mJJ676D95qHloeywcmzFyAebkKm1eiIYoy0y6jKrD8lp8lVc9w-RCYRqdfZbfByo5X_eX8-wXLLrcVRYwyrsIDVGqwfVXZW_30QByJUu4Y0whosMctuhlSvw0nQlnbkxQX7-eb3qHBcA-QadQ3RDkW6EtyPI-wLqMWsFs7Om6KoDTh_kw_8DItVXeEWiAR9kaROoUSjrHcGM0vBM_JShqLiHux0B5e398Q0fzm1Hnx_fkwWzmkbW2E9D-8k2iRyaHqw2YAjv25GkeSSCDsPRPry78V34SOBIf99Oj7bhqUhIy-0U-7A4ux2jl_hg7ujPb_9FjAs4PKtQfEEtEUx8Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Advancing+functional+connectivity+research+from+association+to+causation&rft.jtitle=Nature+neuroscience&rft.au=Reid%2C+Andrew+T&rft.au=Headley%2C+Drew+B&rft.au=Mill%2C+Ravi+D&rft.au=Sanchez-Romero%2C+Ruben&rft.date=2019-11-01&rft.pub=Nature+Publishing+Group&rft.issn=1097-6256&rft.eissn=1546-1726&rft.volume=22&rft.issue=11&rft.spage=1751&rft.epage=1760&rft_id=info:doi/10.1038%2Fs41593-019-0510-4&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1097-6256&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1097-6256&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1097-6256&client=summon