Hspb1 and Lgals3 in spinal neurons are closely associated with autophagy following excitotoxicity based on machine learning algorithms

Excitotoxicity represents the primary cause of neuronal death following spinal cord injury (SCI). While autophagy plays a critical and intricate role in SCI, the specific mechanism underlying the relationship between excitotoxicity and autophagy in SCI has been largely overlooked. In this study, we...

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Veröffentlicht in:	PloS one Jg. 19; H. 5; S. e0303235
Hauptverfasser:	Yan, Lei, Li, Zihao, Li, Chuanbo, Chen, Jingyu, Zhou, Xun, Cui, Jiaming, Liu, Peng, Shen, Chong, Chen, Chu, Hong, Hongxiang, Xu, Guanhua, Cui, Zhiming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 10.05.2024 Public Library of Science (PLoS)
Schlagworte:	Algorithms Animals Apoptosis Autophagy Bioinformatics Calcium-binding protein Cell culture Cell death Data mining Excitotoxicity Galectin 3 - genetics Galectin 3 - metabolism Gene expression Genes Glutamate Glutamic acid Glutamic Acid - metabolism Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Injury analysis Interdisciplinary subjects Learning algorithms Machine Learning Medical diagnosis Molecular biology Molecular Chaperones - genetics Molecular Chaperones - metabolism Neonates Nervous system Network analysis Neurons Neurons - metabolism Penicillin Protein interaction Protein Interaction Maps Protein-protein interactions Proteins Rats Rats, Sprague-Dawley Research methodology S100 protein Spinal cord Spinal Cord - metabolism Spinal Cord - pathology Spinal cord injuries Spinal Cord Injuries - genetics Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Tissue inhibitor of metalloproteinase 1 Transcriptomes
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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