Translational reprogramming marks adaptation to asparagine restriction in cancer

While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. Asparagine limitation in melanoma and pancreatic cancer cell...

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Bibliographic Details
Published in:	Nature cell biology Vol. 21; no. 12; pp. 1590 - 1603
Main Authors:	Pathria, Gaurav, Lee, Joo Sang, Hasnis, Erez, Tandoc, Kristofferson, Scott, David A., Verma, Sachin, Feng, Yongmei, Larue, Lionel, Sahu, Avinash D., Topisirovic, Ivan, Ruppin, Eytan, Ronai, Ze’ev A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2019 Nature Publishing Group
Subjects:	13 13/1 13/106 13/109 13/2 13/44 13/95 38 45 59 631/337/574 631/67 631/67/2327 631/80/86 64 64/60 96 Activating transcription factor 4 Adaptation Amino acids Asparagine Aspartate-ammonia ligase Biomedical and Life Sciences Cancer Cancer Research Care and treatment Cell Biology Deprivation Developmental Biology Gene expression Genetic translation Health aspects Inhibitors Initiation factor eIF-4E Kinases Life Sciences Ligases MAP kinase Medical prognosis Melanoma Pancreatic cancer Protein-tyrosine kinase receptors Rapamycin RNA Scientific equipment and supplies industry Sensitizing Signaling Stem Cells TOR protein Tumors Tyrosine France Canada United States
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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