Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020
Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. Five care homes with no cases and two care ho...
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| Published in: | The Lancet regional health. Europe Vol. 3; p. 100038 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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England
Elsevier Ltd
01.04.2021
Elsevier |
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| ISSN: | 2666-7762, 2666-7762 |
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| Abstract | Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic.
Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks.
Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.
Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home.
We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak.
PHE |
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| AbstractList | Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic.
Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks.
Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.
Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home.
We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak.
PHE Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks. Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (r 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home. We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak. PHE. AbstractBackgroundCare homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. MethodsFive care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks. FindingsAcross seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case. Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (r s 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home. InterpretationWe found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak. FundingPHE Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic.BACKGROUNDCare homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic.Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks.METHODSFive care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks.Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home.FINDINGSAcross seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home.We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak.INTERPRETATIONWe found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak.PHE.FUNDINGPHE. Background: Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. Methods: Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks. Findings: Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home. Interpretation: We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak. Funding: PHE |
| ArticleNumber | 100038 |
| Author | Fok, Jonathan Paranthaman, Karthik Ma, Thomas Ellis, Joanna Myers, Richard Saavedra-Campos, Maria Dun-Campbell, Kate Janarthanan, Roshni Patel, Bharat Wynne-Evans, Edward Fernandez Ruiz De Olano, Elena Tang, Suzanne Brown, Kevin Amin-Chowdhury, Zahin Whitaker, Heather Zambon, Maria Jeffery-Smith, Anna Ramsay, Mary E Shetty, Nandini Rowland, Thomas AJ Bell, Anita Lackenby, Angie Vusirikala, Amoolya Höschler, Katja Sanchez Perez, Marina Aiano, Felicity Ladhani, Shamez Crawley-Boevey, Emma Chow, J. Yimmy |
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Yimmy surname: Chow fullname: Chow, J. Yimmy organization: London Health Protection team, National Infection Service, Public Health England, London, UK – sequence: 28 givenname: Shamez surname: Ladhani fullname: Ladhani, Shamez email: shamez.ladhani@phe.gov.uk organization: Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK – sequence: 29 givenname: Maria surname: Zambon fullname: Zambon, Maria organization: Virus Reference department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK |
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| Cites_doi | 10.1056/NEJMoa2005412 10.46234/ccdcw2020.116 10.2807/1560-7917.ES.2017.22.13.30494 10.1001/jamanetworkopen.2020.17533 10.7554/eLife.58728 10.1016/S2666-7568(20)30012-X 10.1016/j.eclinm.2020.100597 10.1016/j.jhin.2019.02.008 10.1136/bmj.m1808 10.1056/NEJMoa2008457 10.2139/ssrn.3677861 |
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| Keywords | Care home SARS-CoV-2 outbreak Asymptomatic transmission |
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| References | Regular retesting rolled out for care home staff and residents - GOV.UK. Tang S et al. Mass testing after a single suspected or confirmed case of COVID-19 in London care homes: implications for policy and practice. (bib0011) 2020 Burton, Bayne, Evans (bib0018) 2020; 1 Lee, Lee, Lee, Park (bib0012) 2019; 102 Ladhani, Chow, Janarthanan (bib0004) 2020; 0 Watson, Whiting, Brush (bib0020) 2020; 369 Ladhani, Jeffery-Smith, Patel (bib0007) 2020 Accessed October 11, 2020. Arons, Hatfield, Reddy (bib0016) 2020 Accessed October 12, 2020. Shu, McCauley (bib0010) 2017; 22 Emmerson, Adamson, Turner (bib0019) 2020 Coronavirus (COVID-19) in the UK: UK Summary. Niu, Lu, Zhao (bib0008) 2020; 2 Rivett, Sridhar, Sparkes (bib0015) 2020; 9 Deaths involving COVID-19 in the care sector, England and Wales - Office for National Statistics. Ladhani, Chow, Atkin (bib0021) 2020; 0 Zhang, Guo, Wu (bib0014) 2020; 1 Kennelly, Dyer, Noonan (bib0017) 2020 . Belmin, Um-Din, Donadio (bib0002) 2020; 3 Patel, Chaisson, Borgetti (bib0013) June 2020 McMichael, Currie, Clark (bib0001) 2020; 382 Quick (bib0009) 2020 Ladhani, Jeffery-Smith, Patel (bib0023) 2020 10.1016/j.lanepe.2021.100038_bib0003 (10.1016/j.lanepe.2021.100038_bib0011) 2020 Emmerson (10.1016/j.lanepe.2021.100038_bib0019) 2020 10.1016/j.lanepe.2021.100038_bib0022 Ladhani (10.1016/j.lanepe.2021.100038_bib0007) 2020 Arons (10.1016/j.lanepe.2021.100038_bib0016) 2020 Niu (10.1016/j.lanepe.2021.100038_bib0008) 2020; 2 Kennelly (10.1016/j.lanepe.2021.100038_bib0017) 2020 Ladhani (10.1016/j.lanepe.2021.100038_bib0021) 2020; 0 10.1016/j.lanepe.2021.100038_bib0006 McMichael (10.1016/j.lanepe.2021.100038_bib0001) 2020; 382 10.1016/j.lanepe.2021.100038_bib0005 Shu (10.1016/j.lanepe.2021.100038_bib0010) 2017; 22 Ladhani (10.1016/j.lanepe.2021.100038_bib0004) 2020; 0 Watson (10.1016/j.lanepe.2021.100038_bib0020) 2020; 369 Burton (10.1016/j.lanepe.2021.100038_bib0018) 2020; 1 Ladhani (10.1016/j.lanepe.2021.100038_bib0023) 2020 Zhang (10.1016/j.lanepe.2021.100038_bib0014) 2020; 1 Lee (10.1016/j.lanepe.2021.100038_bib0012) 2019; 102 Quick (10.1016/j.lanepe.2021.100038_bib0009) 2020 Belmin (10.1016/j.lanepe.2021.100038_bib0002) 2020; 3 Patel (10.1016/j.lanepe.2021.100038_bib0013) 2020 Rivett (10.1016/j.lanepe.2021.100038_bib0015) 2020; 9 |
| References_xml | – volume: 0 year: 2020 ident: bib0004 article-title: Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020 publication-title: EClinicalMedicine – year: 2020 ident: bib0017 article-title: Asymptomatic carriage rates and case fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes publication-title: Age Ageing – volume: 1 start-page: e21 year: 2020 end-page: e31 ident: bib0018 article-title: Evolution and effects of COVID-19 outbreaks in care homes: a population analysis in 189 care homes in one geographical region of the UK publication-title: Lancet Heal Longev – year: 2020 ident: bib0016 article-title: Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility publication-title: N Engl J Med – volume: 3 year: 2020 ident: bib0002 article-title: Coronavirus disease 2019 outcomes in French nursing homes that implemented staff confinement with residents publication-title: JAMA Netw Open – year: 2020 ident: bib0023 article-title: High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19; a prospective cohort study in England publication-title: medRxiv – year: 2020 ident: bib0009 article-title: Spanish journal of legal medicine ARTIC coronavirus method development community 1 more workspace ARTIC amplicon sequencing protocol for MinION for nCoV-2019 – volume: 0 start-page: 4840 year: 2020 ident: bib0021 article-title: Regular mass screening for SARS-CoV-2 infection in care homes already affected by COVID-19 outbreaks: implications of false positive test results publication-title: J Infect – year: 2020 ident: bib0019 article-title: Risk factors for outbreaks of COVID-19 in care homes following hospital discharge: a national cohort analysis publication-title: SSRN Electron J – volume: 369 start-page: m1808 year: 2020 ident: bib0020 article-title: Interpreting a covid-19 test result publication-title: BMJ – volume: 102 start-page: 377 year: 2019 end-page: 393 ident: bib0012 article-title: Effectiveness and core components of infection prevention and control programmes in long-term care facilities: a systematic review publication-title: J Hosp Infect – volume: 382 start-page: 2008 year: 2020 end-page: 2011 ident: bib0001 article-title: Epidemiology of covid-19 in a long-term care facility in King County, Washington publication-title: N Engl J Med – volume: 2 start-page: 453 year: 2020 end-page: 457 ident: bib0008 article-title: Three novel real-time RT-PCR assays for detection of COVID-19 virus publication-title: China CDC Wkly – year: 2020 ident: bib0011 article-title: Serological surveillance - summary report 3, 6 May 2020 – volume: 1 year: 2020 ident: bib0014 article-title: Factors associated with asymptomatic infection in health-care workers with severe acute respiratory syndrome coronavirus 2 infection in Wuhan, China: a multicentre retrospective cohort study publication-title: Clin Microbiol Infect – volume: 9 year: 2020 ident: bib0015 article-title: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission publication-title: Elife – reference: . Accessed October 11, 2020. – reference: . – reference: Deaths involving COVID-19 in the care sector, England and Wales - Office for National Statistics. – reference: Coronavirus (COVID-19) in the UK: UK Summary. – volume: 22 start-page: 30494 year: 2017 ident: bib0010 article-title: GISAID: Global initiative on sharing all influenza data – from vision to reality publication-title: Eurosurveillance – start-page: 1 year: June 2020 end-page: 7 ident: bib0013 article-title: Asymptomatic SARS-CoV-2 infection and COVID-19 mortality during an outbreak investigation in a skilled nursing facility publication-title: Clin Infect Dis – year: 2020 ident: bib0007 article-title: High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19: Prospective cohort study, England publication-title: EClinicalMedicine – reference: . Accessed October 12, 2020. – reference: Regular retesting rolled out for care home staff and residents - GOV.UK. – reference: Tang S et al. Mass testing after a single suspected or confirmed case of COVID-19 in London care homes: implications for policy and practice. – volume: 382 start-page: 2008 issue: 21 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0001 article-title: Epidemiology of covid-19 in a long-term care facility in King County, Washington publication-title: N Engl J Med doi: 10.1056/NEJMoa2005412 – volume: 2 start-page: 453 issue: 25 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0008 article-title: Three novel real-time RT-PCR assays for detection of COVID-19 virus publication-title: China CDC Wkly doi: 10.46234/ccdcw2020.116 – volume: 22 start-page: 30494 issue: 13 year: 2017 ident: 10.1016/j.lanepe.2021.100038_bib0010 article-title: GISAID: Global initiative on sharing all influenza data – from vision to reality publication-title: Eurosurveillance doi: 10.2807/1560-7917.ES.2017.22.13.30494 – volume: 3 issue: 8 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0002 article-title: Coronavirus disease 2019 outcomes in French nursing homes that implemented staff confinement with residents publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2020.17533 – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0011 – ident: 10.1016/j.lanepe.2021.100038_bib0022 – volume: 0 issue: 0 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0004 article-title: Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020 publication-title: EClinicalMedicine – volume: 9 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0015 article-title: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission publication-title: Elife doi: 10.7554/eLife.58728 – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0017 article-title: Asymptomatic carriage rates and case fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes publication-title: Age Ageing – volume: 1 start-page: e21 issue: 1 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0018 article-title: Evolution and effects of COVID-19 outbreaks in care homes: a population analysis in 189 care homes in one geographical region of the UK publication-title: Lancet Heal Longev doi: 10.1016/S2666-7568(20)30012-X – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0007 article-title: High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19: Prospective cohort study, England publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2020.100597 – volume: 102 start-page: 377 issue: 4 year: 2019 ident: 10.1016/j.lanepe.2021.100038_bib0012 article-title: Effectiveness and core components of infection prevention and control programmes in long-term care facilities: a systematic review publication-title: J Hosp Infect doi: 10.1016/j.jhin.2019.02.008 – volume: 1 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0014 article-title: Factors associated with asymptomatic infection in health-care workers with severe acute respiratory syndrome coronavirus 2 infection in Wuhan, China: a multicentre retrospective cohort study publication-title: Clin Microbiol Infect – volume: 369 start-page: m1808 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0020 article-title: Interpreting a covid-19 test result publication-title: BMJ doi: 10.1136/bmj.m1808 – ident: 10.1016/j.lanepe.2021.100038_bib0003 – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0023 article-title: High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19; a prospective cohort study in England publication-title: medRxiv – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0009 – volume: 0 start-page: 4840 issue: 0 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0021 article-title: Regular mass screening for SARS-CoV-2 infection in care homes already affected by COVID-19 outbreaks: implications of false positive test results publication-title: J Infect – ident: 10.1016/j.lanepe.2021.100038_bib0005 – ident: 10.1016/j.lanepe.2021.100038_bib0006 – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0016 article-title: Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility publication-title: N Engl J Med doi: 10.1056/NEJMoa2008457 – year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0019 article-title: Risk factors for outbreaks of COVID-19 in care homes following hospital discharge: a national cohort analysis publication-title: SSRN Electron J doi: 10.2139/ssrn.3677861 – start-page: 1 year: 2020 ident: 10.1016/j.lanepe.2021.100038_bib0013 article-title: Asymptomatic SARS-CoV-2 infection and COVID-19 mortality during an outbreak investigation in a skilled nursing facility publication-title: Clin Infect Dis |
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| Title | Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020 |
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