Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans

Aims Type 2 diabetes is frequently associated with infectious complications. Swift activation of leucocytes is important for an adequate immune response. We determined the selective effects of hyperglycaemia and hyperinsulinaemia on lipopolysaccharide (LPS)‐induced proinflammatory gene expression a...

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Vydáno v:	Diabetic medicine Ročník 25; číslo 2; s. 157 - 164
Hlavní autoři:	Stegenga, M. E., Crabben, S. N. van der, Dessing, M. C., Pater, J. M., Van Den Pangaart, P. S., De Vos, A. F., Tanck, M. W., Roos, D., Sauerwein, H. P., Van Der Poll, T.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.02.2008 Blackwell
Témata:	Adult Biological and medical sciences cytokines Diabetes Mellitus, Type 2 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endocrinopathies Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene Expression - genetics Glucose Clamp Technique Humans hyperglycaemia Hyperglycemia - metabolism hyperinsulinaemia Hyperinsulinism - metabolism I-kappa B Proteins Interleukin-1alpha - genetics Interleukin-1alpha - metabolism Male Medical sciences mRNA neutrophils Neutrophils - metabolism NF-KappaB Inhibitor alpha Original : Treatment RNA, Messenger - genetics RNA, Messenger - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Endocrinopathy Human Hyperinsulinemia Obesity Nutrition Acute Nutrition disorder Cytokine Granulocyte Metabolic diseases Biosynthesis Inflammation mRNA Gene expression Hyperglycemia Messenger RNA Production hyperglycaemia hyperinsulinaemia cytokines Neutrophil neutrophils Endocrinology Nutritional status
ISSN:	0742-3071, 1464-5491, 1464-5491
On-line přístup:	Získat plný text
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