The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

Polycomb group (PcG) proteins form transcriptional repressor complexes with well‐established functions during cell‐fate determination. Yet, the mechanisms underlying their regulation remain poorly understood. Here, we extend the role of Polycomb complexes in the temporal control of neural progenitor...

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Bibliographic Details
Published in:	The EMBO journal Vol. 32; no. 11; pp. 1598 - 1612
Main Authors:	Sparmann, Anke, Xie, Yunli, Verhoeven, Els, Vermeulen, Michiel, Lancini, Cesare, Gargiulo, Gaetano, Hulsman, Danielle, Mann, Matthias, Knoblich, Juergen A, van Lohuizen, Maarten
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 29.05.2013 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Subjects:	Animals Astrocytes - cytology Astrocytes - metabolism astrogenesis Cell Differentiation Cell Line Cells Chd4 Chromatin Immunoprecipitation Deoxyribonucleic acid Developmental stages differentiation DNA DNA Helicases - genetics DNA Helicases - metabolism EMBO09 EMBO27 Embryo, Mammalian Enhancer of Zeste Homolog 2 Protein Female Gene Expression Regulation, Developmental Glial Fibrillary Acidic Protein Histones - chemistry Histones - metabolism Mice Mice, Inbred C57BL Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neural networks neural stem cells Neural Stem Cells - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism polycomb Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Pregnancy Promoter Regions, Genetic Proteins Signal transduction astrogenesis differentiation Chd4 neural stem cells polycomb
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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