Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

Neuromyelitis optica (NMO) is an autoimmune disease targeting aquaporin 4 (AQP4), localized mainly at the astrocytic foot processes. Loss of AQP4 and glial fibrillary acidic protein (GFAP) was reported, but the pathological significance of astrocytopathy is still controversial. Here we show that act...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 125; no. 6; pp. 815 - 827
Main Authors:	Misu, Tatsuro, Höftberger, Romana, Fujihara, Kazuo, Wimmer, Isabella, Takai, Yoshiki, Nishiyama, Shuhei, Nakashima, Ichiro, Konno, Hidehiko, Bradl, Monika, Garzuly, Ferenc, Itoyama, Yasuto, Aoki, Masashi, Lassmann, Hans
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.06.2013 Springer Springer Nature B.V
Subjects:	Adult Aged Aged, 80 and over Antibodies Apoptosis Aquaporin 1 - physiology Aquaporin 4 - physiology Aquaporins Astrocytes - metabolism Astrocytes - pathology Brain - metabolism Brain - pathology Brain research Cohort Studies Female Glial Fibrillary Acidic Protein - physiology Granulocytes Hospitals Humans Male Medicine Medicine & Public Health Middle Aged Multiple sclerosis Nervous system Neurodegeneration Neurology Neuromyelitis optica Neuromyelitis Optica - etiology Neuromyelitis Optica - metabolism Neuromyelitis Optica - pathology Neurosciences Original Paper Pathology Patients Spinal cord Spinal Cord - metabolism Spinal Cord - pathology Young Adult Austria Japan Neuromyelitis optica Complement Astrocytes Demyelination
ISSN:	0001-6322, 1432-0533, 1432-0533
Online Access:	Get full text
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