Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

Neuromyelitis optica (NMO) is an autoimmune disease targeting aquaporin 4 (AQP4), localized mainly at the astrocytic foot processes. Loss of AQP4 and glial fibrillary acidic protein (GFAP) was reported, but the pathological significance of astrocytopathy is still controversial. Here we show that act...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Acta neuropathologica Ročník 125; číslo 6; s. 815 - 827
Hlavní autoři:	Misu, Tatsuro, Höftberger, Romana, Fujihara, Kazuo, Wimmer, Isabella, Takai, Yoshiki, Nishiyama, Shuhei, Nakashima, Ichiro, Konno, Hidehiko, Bradl, Monika, Garzuly, Ferenc, Itoyama, Yasuto, Aoki, Masashi, Lassmann, Hans
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer-Verlag 01.06.2013 Springer Springer Nature B.V
Témata:	Adult Aged Aged, 80 and over Antibodies Apoptosis Aquaporin 1 - physiology Aquaporin 4 - physiology Aquaporins Astrocytes - metabolism Astrocytes - pathology Brain - metabolism Brain - pathology Brain research Cohort Studies Female Glial Fibrillary Acidic Protein - physiology Granulocytes Hospitals Humans Male Medicine Medicine & Public Health Middle Aged Multiple sclerosis Nervous system Neurodegeneration Neurology Neuromyelitis optica Neuromyelitis Optica - etiology Neuromyelitis Optica - metabolism Neuromyelitis Optica - pathology Neurosciences Original Paper Pathology Patients Spinal cord Spinal Cord - metabolism Spinal Cord - pathology Young Adult Austria Japan Neuromyelitis optica Complement Astrocytes Demyelination
ISSN:	0001-6322, 1432-0533, 1432-0533
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!