Estrogen receptor 1 gene polymorphisms and decreased risk of obesity in women

Estrogen receptor α gene ( ESR1) polymorphisms have been associated with several diseases, but whether they are associated with obesity is uncertain. To elucidate the role of genetic variation in the ESR1 gene with body mass index (BMI), 543 white women (median age, 63 years) from the Women's H...

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Vydáno v:Metabolism, clinical and experimental Ročník 58; číslo 6; s. 759 - 764
Hlavní autoři: Goulart, Alessandra C., Zee, Robert Y.L., Rexrode, Kathryn M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Elsevier Inc 01.06.2009
Elsevier
Témata:
Age
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Body Mass Index
Endocrinology & Metabolism
Estrogen Receptor alpha - genetics
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - genetics
Odds Ratio
Polymorphism, Genetic
Postmenopause
Risk
Vertebrates: anatomy and physiology, studies on body, several organs or systems
White People - genetics
Human
Obesity
Estrogen receptor
Nutrition disorder
Estrogen
Risk
Ovarian hormone
Gene
Risk factor
Female
Sex steroid hormone
Woman
Endocrinology
Nutritional status
Polymorphism
Hormonal receptor
ISSN:0026-0495, 1532-8600, 1532-8600
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Shrnutí:Estrogen receptor α gene ( ESR1) polymorphisms have been associated with several diseases, but whether they are associated with obesity is uncertain. To elucidate the role of genetic variation in the ESR1 gene with body mass index (BMI), 543 white women (median age, 63 years) from the Women's Health Study were examined. Most were postmenopausal (99.3%). The relationships between rs2234693 and rs9340799 genotypes and their associated haplotypes with obesity (BMI ≥30 kg/m 2) and overweight (BMI ≥25 kg/m 2) were evaluated. Among women with the rs2234693 TT genotype, 18.3% were obese, whereas only 8.2% of those with the CC genotype were obese ( P = .04). In a logistic regression model assuming additive inheritance, rs2234693 was associated with decreased odds of obesity (BMI ≥30 kg/m 2) (crude odds ratio = 0.63, 95% confidence interval = 0.44-0.90, P = .01). For rs9340799, only an inverse trend was observed for BMI ( P = .08). Haplotypes that included the variant C allele were associated with a reduced risk of obesity (crude odds ratio = 0.65, 95% confidence interval = 0.44-0.94, P = .02 for C-G). The rs2234693 C allele of ESR1 and its associated genotypes and haplotypes were inversely and consistently associated with obesity. One or more copies of the C allele were associated with decreased risk of obesity in white postmenopausal women.
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ISSN:0026-0495
1532-8600
1532-8600
DOI:10.1016/j.metabol.2009.01.003