Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

Background COVID-19 is characterized by severe acute lung injury, which is associated with neutrophil infiltration and the release of neutrophil extracellular traps (NETs). COVID-19 treatment options are scarce. Previous work has shown an increase in NETs release in the lung and plasma of COVID-19 p...

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Bibliographic Details
Published in:	Respiratory research Vol. 24; no. 1; pp. 66 - 11
Main Authors:	Veras, Flavio P., Gomes, Giovanni F., Silva, Bruna M. S., Caetité, Diego B., Almeida, Cicero J. L. R., Silva, Camila Meirelles S., Schneider, Ayda H., Corneo, Emily S., Bonilha, Caio S., Batah, Sabrina S., Martins, Ronaldo, Arruda, Eurico, Fabro, Alexandre T., Alves-Filho, José C., Cunha, Thiago M., Cunha, Fernando Q.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 02.03.2023 BioMed Central Ltd Nature Publishing Group BMC
Subjects:	Acute Lung Injury Animal models Animals Antibodies Apoptosis Chemokines Clinical outcomes Cloning Coronaviruses COVID-19 COVID-19 Drug Treatment Cytokines Deoxyribonuclease Deoxyribonuclease I - pharmacology Deoxyribonuclease I - therapeutic use Disease Disease Models, Animal Extracellular Traps Health aspects Health services Heart diseases Histopathology Humans Infections Injuries Injury prevention Kidneys Kinases Laboratories Leukocytes (neutrophilic) Lung diseases Lungs Medicine Medicine & Public Health Mice Multiple organ failure Neutrophil extracellular traps Neutrophils Organ damage Pathophysiology Pneumology/Respiratory System Prevention Risk factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Brazil COVID-19 SARS-CoV-2 Organ damage Neutrophil extracellular traps Neutrophils
ISSN:	1465-993X, 1465-9921, 1465-993X
Online Access:	Get full text
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