Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

Purpose To examine the association of red meat and whole-grain bread consumption with plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation and obesity. Methods Our cross-sectional study was based on 2,198 men and women who were selected as a sub-cohort for an inv...

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Published in:European journal of nutrition Vol. 52; no. 1; pp. 337 - 345
Main Authors: Montonen, Jukka, Boeing, Heiner, Fritsche, Andreas, Schleicher, Erwin, Joost, Hans-Georg, Schulze, Matthias B., Steffen, Annika, Pischon, Tobias
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01.02.2013
Springer Nature B.V
Subjects:
adiponectin
Adiponectin - blood
aerobiosis
alanine transaminase
Alanine Transaminase - blood
alpha-2-HS-Glycoprotein
alpha-2-HS-Glycoprotein - analysis
alpha-2-HS-Glycoprotein - metabolism
analysis
Animals
biomarkers
Biomarkers - blood
blood
Blood Glucose
Blood Glucose - metabolism
Body Mass Index
Bread
breads
C-Reactive Protein
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - metabolism
Cattle
Chemistry
Chemistry and Materials Science
Cholesterol, HDL
Cholesterol, HDL - blood
Cross-Sectional Studies
diabetes
Diet
Edible Grain
Female
gamma-glutamyltransferase
gamma-Glutamyltransferase - blood
glucose
Glycated Hemoglobin
Glycated Hemoglobin A - analysis
Glycated Hemoglobin A - metabolism
glycohemoglobin
high density lipoprotein cholesterol
Humans
inflammation
Inflammation - blood
Inflammation - metabolism
Life Style
lifestyle
Male
Meat
meat consumption
metabolism
Middle Aged
Nutrition
obesity
Obesity - blood
Obesity - metabolism
Original Contribution
Oxidative Stress
Prospective Studies
questionnaires
red meat
sampling
Surveys and Questionnaires
triacylglycerols
Triglycerides
Triglycerides - blood
Waist Circumference
whole grain foods
Whole grain
Biomarkers
Glucose metabolism
Red meat
ISSN:1436-6207, 1436-6215, 1436-6215
Online Access:Get full text
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Summary:Purpose To examine the association of red meat and whole-grain bread consumption with plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation and obesity. Methods Our cross-sectional study was based on 2,198 men and women who were selected as a sub-cohort for an investigation of biological predictors of diabetes and cardiovascular diseases from the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Circulating levels of glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase, alanine-aminotransferase, fetuin-A, HDL-cholesterol and triglycerides were measured from random blood samples. Diet and lifestyle data were assessed by questionnaires, and anthropometric data were measured. Results After multivariable adjustment, higher consumption of whole-grain bread was significantly ( P trend <0.05) associated with lower levels of GGT, ALT and hs-CRP, whereas higher consumption of red meat was significantly associated with higher levels of GGT and hs-CRP when adjusted for potential confounding factors related to lifestyle and diet. Further adjustment for body mass index and waist circumference attenuated the association between red meat and hs-CRP ( P  = 0.19). Conclusions The results of this study suggest that high consumption of whole-grain bread is related to lower levels of GGT, ALT and hs-CRP, whereas high consumption of red meat is associated with higher circulating levels of GGT and hs-CRP.
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ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-012-0340-6