Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

The epidermal growth factor receptor (EGFR) and Notch signaling pathways have antagonistic roles during epidermal differentiation and carcinogenesis. The molecular mechanisms regulating the crosstalk between EGFR and Notch during epidermal transformation are largely unknown. We found enhanced EGFR-d...

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Bibliographic Details
Published in:	Oncogene Vol. 29; no. 20; pp. 2950 - 2961
Main Authors:	Rocher-Ros, V, Marco, S, Mao, J-H, Gines, S, Metzger, D, Chambon, P, Balmain, A, Saura, C A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.05.2010 Nature Publishing Group Nature Publishing Group [1987-....]
Subjects:	631/208/200 631/80/86 692/420/755 Animals Apoptosis Biochemistry, Molecular Biology Biological and medical sciences Blotting, Western Carcinogenesis Catalysis Cell Biology Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells, Cultured Cellular signal transduction Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Epidermal growth factor Epidermal growth factor receptors Epidermis F-Box Proteins - metabolism F-Box-WD Repeat-Containing Protein 7 Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetic aspects Genetic regulation Genetics Growth factor receptors Human Genetics Hyperplasia Immunoenzyme Techniques Integrases - metabolism Internal Medicine Intracellular signalling Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Life Sciences Ligases Medicine Medicine & Public Health Mice Mice, Knockout Molecular and cellular biology Molecular biology Molecular modelling Notch1 protein Oncology original-article Physiological aspects Presenilin Presenilins - physiology Proteasomes Receptor, Epidermal Growth Factor - metabolism Secretase Signal transduction Signal Transduction - physiology Transcription Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination France Spain carcinogenesis γ-secretase Fbw7 Notch epidermis Carbon-nitrogen ligases Enzyme Ligases Presenilin Epidermis Carcinogenesis Ubiquitin-protein ligase Cell signaling
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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