Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

Rad51 plays a central role in homologous recombination pathways. Now work with Xenopus laevis egg extracts shows that Rad51 prevents formation of DNA gaps at or behind replication forks, which are dependent on Mre11 nuclease activity. The role of Rad51 in an unperturbed cell cycle has been difficult...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 17; no. 11; pp. 1305 - 1311
Main Authors:	Hashimoto, Yoshitami, Ray Chaudhuri, Arnab, Lopes, Massimo, Costanzo, Vincenzo
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2010 Nature Publishing Group
Subjects:	631/337/1427 631/337/151 Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Biosynthesis Cell cycle Cellular proteins Chromatin - metabolism Deoxyribonucleic acid DNA DNA Damage DNA repair DNA replication DNA Replication - physiology DNA synthesis DNA, Single-Stranded - metabolism DNA, Single-Stranded - ultrastructure DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - physiology Life Sciences Membrane Biology Molecular biology MRE11 Homologue Protein Proliferating Cell Nuclear Antigen - physiology Properties Protein Structure Proteolysis Rad51 Recombinase - metabolism Rad51 Recombinase - physiology Xenopus laevis Xenopus Proteins - antagonists & inhibitors Xenopus Proteins - metabolism Xenopus Proteins - physiology United Kingdom Switzerland
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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