Identification of atrial fibrillation associated genes and functional non-coding variants
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes,...
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| Vydáno v: | Nature Communications Ročník 10; číslo 1; s. 4755 - 14 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
Springer Science and Business Media LLC
18.10.2019
Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
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| ISSN: | 2041-1723, 2041-1723 |
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| Abstract | Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in
Gja1
(Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations.
The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and functional non-coding variants. |
|---|---|
| AbstractList | The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and functional non-coding variants. Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations. Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations. The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and functional non-coding variants. Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations.Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations. Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations. The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and functional non-coding variants. Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes, here we cross-reference human transcriptomic, epigenomic and chromatin conformation datasets. Of 104 genetic variant regions associated with atrial fibrillation candidate target genes are prioritized. We optimize EMERGE enhancer prediction and use accessible chromatin profiles of human atrial cardiomyocytes to more accurately predict cardiac regulatory elements and identify hundreds of sub-threshold variants that co-localize with regulatory elements. Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression. Our analyses provide a shortlist of genes likely affected by atrial fibrillation-associated variants and provide variant regulatory elements in each region that link genetic variation and target gene regulation, helping to focus future investigations. |
| ArticleNumber | 4755 |
| Author | Fernanda M Bosada Koen T. Scholman Marie-José Goumans Patrick T. Ellinor Igor R. Efimov Lindsey E. Montefiori Marcelo A. Nobrega Bastiaan J. Boukens Phil Barnett James F. Martin Karel van Duijvenboden Antoine A.F. de Vries Vincent M. Christoffels Jia Liu Antoinette F. van Ouwerkerk Matthew C. Hill |
| Author_xml | – sequence: 1 givenname: Antoinette F. orcidid: 0000-0002-1583-1785 surname: van Ouwerkerk fullname: van Ouwerkerk, Antoinette F. organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 2 givenname: Fernanda M. surname: Bosada fullname: Bosada, Fernanda M. organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 3 givenname: Karel surname: van Duijvenboden fullname: van Duijvenboden, Karel organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 4 givenname: Matthew C. orcidid: 0000-0003-4578-3873 surname: Hill fullname: Hill, Matthew C. organization: Program in Developmental Biology, Baylor College of Medicine – sequence: 5 givenname: Lindsey E. surname: Montefiori fullname: Montefiori, Lindsey E. organization: Department of Human Genetics, The University of Chicago – sequence: 6 givenname: Koen T. surname: Scholman fullname: Scholman, Koen T. organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 7 givenname: Jia surname: Liu fullname: Liu, Jia organization: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Department of Cell Biology and Genetics, Center for Anti-ageing and Regenerative Medicine, Shenzhen Key Laboratory for Anti-ageing and Regenerative Medicine, Shenzhen University Medical School, Shenzhen University, Nanhai Ave, Netherlands Heart Institute, Holland Heart House – sequence: 8 givenname: Antoine A. F. surname: de Vries fullname: de Vries, Antoine A. F. organization: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Netherlands Heart Institute, Holland Heart House – sequence: 9 givenname: Bastiaan J. surname: Boukens fullname: Boukens, Bastiaan J. organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 10 givenname: Patrick T. orcidid: 0000-0002-2067-0533 surname: Ellinor fullname: Ellinor, Patrick T. organization: Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cardiovasular Research Center, Massachusetts General Hospital, Cardiac Arrhythmia Service, Massachusetts General Hospital – sequence: 11 givenname: Marie José T. H. orcidid: 0000-0001-9344-6746 surname: Goumans fullname: Goumans, Marie José T. H. organization: Department of Cell and Chemical Biology, Leiden University Medical Center – sequence: 12 givenname: Igor R. orcidid: 0000-0002-1483-5039 surname: Efimov fullname: Efimov, Igor R. organization: Department of Biomedical Engineering, George Washington University – sequence: 13 givenname: Marcelo A. surname: Nobrega fullname: Nobrega, Marcelo A. organization: Department of Human Genetics, The University of Chicago – sequence: 14 givenname: Phil surname: Barnett fullname: Barnett, Phil organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center – sequence: 15 givenname: James F. surname: Martin fullname: Martin, James F. organization: Program in Developmental Biology, Baylor College of Medicine, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Texas Heart Institute, Cardiovascular Research Institute, Baylor College of Medicine – sequence: 16 givenname: Vincent M. surname: Christoffels fullname: Christoffels, Vincent M. email: v.m.christoffels@amsterdamumc.nl organization: Department of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center |
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| Cites_doi | 10.1172/JCI62613 10.1161/CIRCULATIONAHA.114.009892 10.1016/j.cardiores.2003.11.035 10.1016/j.ajhg.2017.12.003 10.1126/science.1232033 10.1101/gr.105361.110 10.1038/nature12753 10.1016/j.cell.2012.03.051 10.1038/ng.2870 10.1038/nprot.2008.211 10.1016/j.hrthm.2013.10.051 10.1038/ng.3286 10.1128/MCB.01384-09 10.1093/cvr/cvv283 10.1161/CIRCRESAHA.114.302226 10.1161/CIRCRESAHA.115.306337 10.1093/nar/gkq319 10.1038/nature11049 10.1038/ng.2261 10.1093/nar/gkl822 10.1038/nrm1151 10.1161/CIRCGENETICS.111.961631 10.1038/ng.3842 10.1038/ng.537 10.1093/bioinformatics/bty141 10.1016/j.cell.2014.11.021 10.1038/nrm.2016.138 10.1038/ng.2416 10.1126/science.aau0320 10.1038/ncomms10190 10.1161/01.CIR.0000074206.52056.2D 10.1038/ng.3843 10.1038/nature06007 10.1074/jbc.M010378200 10.1038/ejhg.2015.269 10.1016/j.cell.2012.01.010 10.1161/CIRCEP.111.966580 10.1038/ng.3014 10.1016/j.jacc.2013.12.015 10.1016/j.yjmcc.2015.06.005 10.1161/CIR.0000000000000040 10.1016/j.ajhg.2018.04.002 10.1161/01.RES.0000122382.19400.14 10.1161/CIRCULATIONAHA.113.005119 10.1016/j.bbamcr.2015.11.025 10.1038/s41588-018-0171-3 10.1038/s41598-017-00043-9 10.1038/nature11082 10.1038/ng.417 10.1186/s13059-014-0550-8 10.1126/science.1222794 10.1093/nar/gkp045 10.1093/bioinformatics/bts635 10.1128/MCB.00728-07 10.1155/2015/798768 10.1007/s00210-009-0474-0.Cardiac 10.1371/journal.pgen.1003750 10.1016/j.cell.2016.09.018 10.1371/journal.pgen.1002824 10.1016/j.cell.2015.06.060 10.3791/4205 10.1172/JCI73140 10.1038/s41467-018-07399-0 10.1016/j.devcel.2013.04.017 10.1371/journal.pone.0026389 10.1016/j.molcel.2010.05.004 10.7554/eLife.35788 10.1371/journal.pgen.1003652 10.1016/j.cell.2019.01.020 10.1242/jcs.143743 10.1093/nar/gkv1144 10.1016/j.cell.2016.01.004 10.1016/j.cell.2016.07.012 10.1371/journal.pone.0092903 10.1093/cvr/cvy134 10.1038/jhg.2015.44 |
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| PublicationTitle | Nature Communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2019 |
| Publisher | Springer Science and Business Media LLC Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Springer Science and Business Media LLC – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Van Den Boogaard (CR25) 2012; 122 Gudbjartsson (CR8) 2009; 41 Dobin (CR73) 2013 Pasquali (CR21) 2014; 46 MacLennan, Kranias (CR55) 2003 Wei, Zhang, Fang, Li, Wang (CR58) 2018 CR38 CR37 Nora (CR31) 2012; 485 CR36 Mifsud (CR41) 2015; 47 CR35 CR33 Chugh (CR1) 2014; 129 CR76 Heijman, Voigt, Nattel, Dobrev (CR48) 2014; 114 CR72 Ellinor (CR6) 2012; 44 Rao (CR42) 2014; 159 CR71 Lin (CR43) 2003 CR70 Christophersen (CR9) 2017; 49 Ruiz-Villalba (CR52) 2017 Brandenburg, Arakel, Schwappach, Lehnart (CR49) 2016 Wang (CR40) 2016; 5 Gallagher, Chen-Plotkin (CR61) 2018; 102 Christophersen (CR16) 2017; 49 de Laat, Duboule (CR28) 2013; 502 Love, Huber, Anders (CR74) 2014 Wasserman, Aneas, Nobrega (CR18) 2010; 20 Rohr (CR54) 2004; 62 CR47 CR45 Krijger, De Laat (CR32) 2016; 17 Ruijter (CR79) 2009 Gudbjartsson (CR4) 2007; 448 Deng (CR27) 2012; 149 Sander (CR77) 2010 Berry (CR56) 2001; 276 Tsai (CR3) 2016; 7 Tucker, Clauss, Ellinor (CR13) 2016; 109 Huang, Sherman, Lempicki (CR75) 2009 CR57 CR12 Ellinor (CR5) 2010; 42 Nielsen (CR17) 2018 Maurano (CR19) 2012; 337 CR51 Lubitz (CR7) 2014 Fadista, Manning, Florez, Groop (CR39) 2016 Lin (CR46) 2014; 11 Nielsen (CR11) 2018; 102 Sinner (CR14) 2014; 130 Low (CR10) 2017; 49 Jansen (CR68) 2012 Mali (CR78) 2013; 339 Arking (CR63) 2014; 46 Camelliti, Green, LeGrice, Kohl (CR53) 2004; 94 Visel, Minovitsky, Dubchak, Pennacchio (CR59) 2007; 35 CR26 CR69 CR24 Dixon (CR29) 2012; 485 Wright, Brown, Cole (CR23) 2010; 30 CR67 Furlong, Levine (CR34) 2018 CR66 CR65 Martin (CR15) 2015; 85 CR20 CR64 Cowper-Sallari (CR22) 2012; 44 Sexton (CR30) 2012; 148 CR62 Hsu (CR44) 2012; 5 CR60 Preissl (CR50) 2015; 117 January (CR2) 2014; 130 B Mifsud (12721_CR41) 2015; 47 12721_CR47 12721_CR45 DE Arking (12721_CR63) 2014; 46 RIR Martin (12721_CR15) 2015; 85 X Wang (12721_CR40) 2016; 5 WS Lin (12721_CR43) 2003 A Visel (12721_CR59) 2007; 35 W Deng (12721_CR27) 2012; 149 EEM Furlong (12721_CR34) 2018 P Mali (12721_CR78) 2013; 339 DH MacLennan (12721_CR55) 2003 H Lin (12721_CR46) 2014; 11 DF Gudbjartsson (12721_CR8) 2009; 41 12721_CR36 NF Wasserman (12721_CR18) 2010; 20 12721_CR37 12721_CR38 12721_CR76 W de Laat (12721_CR28) 2013; 502 12721_CR33 12721_CR35 SSP Rao (12721_CR42) 2014; 159 12721_CR72 A Ruiz-Villalba (12721_CR52) 2017 PT Ellinor (12721_CR6) 2012; 44 12721_CR70 12721_CR71 L Pasquali (12721_CR21) 2014; 46 J Hsu (12721_CR44) 2012; 5 R Cowper-Sallari (12721_CR22) 2012; 44 S Brandenburg (12721_CR49) 2016 CT January (12721_CR2) 2014; 130 MF Sinner (12721_CR14) 2014; 130 CT Tsai (12721_CR3) 2016; 7 JB Nielsen (12721_CR11) 2018; 102 12721_CR69 12721_CR26 12721_CR65 12721_CR66 12721_CR67 12721_CR24 12721_CR62 12721_CR20 12721_CR64 S Rohr (12721_CR54) 2004; 62 12721_CR60 A Dobin (12721_CR73) 2013 JB Wright (12721_CR23) 2010; 30 J Heijman (12721_CR48) 2014; 114 MD Gallagher (12721_CR61) 2018; 102 JR Dixon (12721_CR29) 2012; 485 JA Jansen (12721_CR68) 2012 NR Tucker (12721_CR13) 2016; 109 JB Nielsen (12721_CR17) 2018 T Sexton (12721_CR30) 2012; 148 EP Nora (12721_CR31) 2012; 485 DW Huang (12721_CR75) 2009 DF Gudbjartsson (12721_CR4) 2007; 448 M Van Den Boogaard (12721_CR25) 2012; 122 SS Chugh (12721_CR1) 2014; 129 MT Maurano (12721_CR19) 2012; 337 P Camelliti (12721_CR53) 2004; 94 PHL Krijger (12721_CR32) 2016; 17 12721_CR12 12721_CR57 IE Christophersen (12721_CR16) 2017; 49 JD Sander (12721_CR77) 2010 JM Ruijter (12721_CR79) 2009 12721_CR51 MI Love (12721_CR74) 2014 PT Ellinor (12721_CR5) 2010; 42 S Preissl (12721_CR50) 2015; 117 Z Wei (12721_CR58) 2018 S-K Low (12721_CR10) 2017; 49 FB Berry (12721_CR56) 2001; 276 SA Lubitz (12721_CR7) 2014 IE Christophersen (12721_CR9) 2017; 49 J Fadista (12721_CR39) 2016 32623450 - Cardiovasc Res. 2020 Jul 15;116(9):e106-e108. doi: 10.1093/cvr/cvaa166 |
| References_xml | – volume: 122 start-page: 2519 year: 2012 end-page: 2530 ident: CR25 article-title: Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer publication-title: J. Clin. Invest. doi: 10.1172/JCI62613 – ident: CR45 – ident: CR70 – volume: 130 start-page: 1225 year: 2014 end-page: 1235 ident: CR14 article-title: Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.114.009892 – volume: 62 start-page: 309 year: 2004 end-page: 322 ident: CR54 article-title: Role of gap junctions in the propagation of the cardiac action potential publication-title: Cardiovasc. Res. doi: 10.1016/j.cardiores.2003.11.035 – volume: 102 start-page: 103 year: 2018 end-page: 115 ident: CR11 article-title: Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2017.12.003 – volume: 339 start-page: 819 year: 2013 end-page: 823 ident: CR78 article-title: RNA-Guided Human Genome Engineering via Cas9 publication-title: Science doi: 10.1126/science.1232033 – ident: CR51 – ident: CR12 – volume: 20 start-page: 1191 year: 2010 end-page: 1197 ident: CR18 article-title: An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer publication-title: Genome Res. doi: 10.1101/gr.105361.110 – volume: 502 start-page: 499 year: 2013 end-page: 506 ident: CR28 article-title: Topology of mammalian developmental enhancers and their regulatory landscapes publication-title: Nature doi: 10.1038/nature12753 – volume: 149 start-page: 1233 year: 2012 end-page: 1244 ident: CR27 article-title: Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor publication-title: Cell doi: 10.1016/j.cell.2012.03.051 – volume: 46 start-page: 136 year: 2014 end-page: 143 ident: CR21 article-title: Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants publication-title: Nat. Genet. doi: 10.1038/ng.2870 – year: 2009 ident: CR75 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat. Protoc. doi: 10.1038/nprot.2008.211 – volume: 11 start-page: 266 year: 2014 end-page: 271 ident: CR46 article-title: Gene expression and genetic variation in human atria publication-title: Heart Rhythm. doi: 10.1016/j.hrthm.2013.10.051 – ident: CR35 – volume: 47 start-page: 598 year: 2015 end-page: 606 ident: CR41 article-title: Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C publication-title: Nat. Genet. doi: 10.1038/ng.3286 – volume: 30 start-page: 1411 year: 2010 end-page: 1420 ident: CR23 article-title: Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01384-09 – volume: 109 start-page: 493 year: 2016 end-page: 501 ident: CR13 article-title: Common variation in atrial fibrillation: Navigating the path from genetic association to mechanism publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvv283 – volume: 114 start-page: 1483 year: 2014 end-page: 1499 ident: CR48 article-title: Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.114.302226 – volume: 117 start-page: 413 year: 2015 end-page: 423 ident: CR50 article-title: Deciphering the epigenetic code of cardiac myocyte transcription publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.115.306337 – year: 2010 ident: CR77 article-title: ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq319 – volume: 485 start-page: 381 year: 2012 end-page: 385 ident: CR31 article-title: Spatial partitioning of the regulatory landscape of the X-inactivation centre publication-title: Nature doi: 10.1038/nature11049 – volume: 44 start-page: 670 year: 2012 end-page: 675 ident: CR6 article-title: Meta-analysis identifies six new susceptibility loci for atrial fibrillation publication-title: Nat. Genet. doi: 10.1038/ng.2261 – volume: 5 start-page: 1 year: 2016 end-page: 24 ident: CR40 article-title: Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures publication-title: eLife – ident: CR71 – volume: 35 start-page: 88 year: 2007 end-page: 92 ident: CR59 article-title: VISTA Enhancer Browser—A database of tissue-specific human enhancers publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl822 – year: 2003 ident: CR55 article-title: Phospholamban: a crucial regulator of cardiac contractility publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1151 – volume: 5 start-page: 327 year: 2012 end-page: 335 ident: CR44 article-title: Whole genome expression differences in human left and right atria ascertained by RNA sequencing publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.111.961631 – volume: 49 start-page: 953 year: 2017 end-page: 958 ident: CR10 article-title: Identification of six new genetic loci associated with atrial fibrillation in the Japanese population publication-title: Nat. Genet. doi: 10.1038/ng.3842 – ident: CR67 – volume: 42 start-page: 240 year: 2010 end-page: 244 ident: CR5 article-title: Common variants in KCNN3 are associated with lone atrial fibrillation publication-title: Nat. Genet. doi: 10.1038/ng.537 – year: 2018 ident: CR58 article-title: esATAC: an easy-to-use systematic pipeline for ATAC-seq data analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/bty141 – volume: 159 start-page: 1665 year: 2014 end-page: 1680 ident: CR42 article-title: A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping publication-title: Cell doi: 10.1016/j.cell.2014.11.021 – ident: CR57 – volume: 17 start-page: 771 year: 2016 end-page: 782 ident: CR32 article-title: Regulation of disease-associated gene expression in the 3D genome publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2016.138 – ident: CR60 – ident: CR36 – volume: 44 start-page: 1191 year: 2012 end-page: 1198 ident: CR22 article-title: Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression publication-title: Nat. Genet. doi: 10.1038/ng.2416 – year: 2018 ident: CR34 article-title: Developmental enhancers and chromosome topology publication-title: Science doi: 10.1126/science.aau0320 – volume: 7 start-page: 1 year: 2016 end-page: 9 ident: CR3 article-title: Genome-wide screening identifies a KCNIP1 copy number variant as a genetic predictor for atrial fibrillation publication-title: Nat. Commun. doi: 10.1038/ncomms10190 – ident: CR64 – year: 2003 ident: CR43 article-title: Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopy publication-title: Circulation doi: 10.1161/01.CIR.0000074206.52056.2D – ident: CR26 – volume: 49 start-page: 946 year: 2017 end-page: 952 ident: CR9 article-title: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation publication-title: Nat. Genet. doi: 10.1038/ng.3843 – volume: 448 start-page: 353 year: 2007 end-page: 357 ident: CR4 article-title: Variants conferring risk of atrial fibrillation on chromosome 4q25 publication-title: Nature doi: 10.1038/nature06007 – volume: 276 start-page: 25057 year: 2001 end-page: 25065 ident: CR56 article-title: Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010378200 – ident: CR66 – ident: CR47 – ident: CR72 – ident: CR37 – year: 2016 ident: CR39 article-title: The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants publication-title: Eur. J. Hum. Genet. doi: 10.1038/ejhg.2015.269 – volume: 148 start-page: 458 year: 2012 end-page: 472 ident: CR30 article-title: Three-dimensional folding and functional organization principles of the Drosophila genome publication-title: Cell doi: 10.1016/j.cell.2012.01.010 – year: 2012 ident: CR68 article-title: Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity publication-title: Circ. Arrhythmia Electrophysiol. doi: 10.1161/CIRCEP.111.966580 – ident: CR33 – volume: 46 start-page: 826 year: 2014 end-page: 836 ident: CR63 article-title: Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization publication-title: Nat. Genet. doi: 10.1038/ng.3014 – year: 2014 ident: CR7 article-title: Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2013.12.015 – volume: 85 start-page: 207 year: 2015 end-page: 214 ident: CR15 article-title: Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2015.06.005 – volume: 130 start-page: 2071 year: 2014 end-page: 2104 ident: CR2 article-title: 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society publication-title: Circulation doi: 10.1161/CIR.0000000000000040 – volume: 102 start-page: 717 year: 2018 end-page: 730 ident: CR61 article-title: The Post-GWAS Era: From Association to Function publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2018.04.002 – volume: 94 start-page: 828 year: 2004 end-page: 835 ident: CR53 article-title: Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling publication-title: Circ. Res. doi: 10.1161/01.RES.0000122382.19400.14 – ident: CR69 – volume: 129 start-page: 837 year: 2014 end-page: 847 ident: CR1 article-title: Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.005119 – year: 2016 ident: CR49 article-title: The molecular and functional identities of atrial cardiomyocytes in health and disease publication-title: Biochimica et. Biophysica Acta—Mol. Cell Res. doi: 10.1016/j.bbamcr.2015.11.025 – year: 2018 ident: CR17 article-title: Biobank-driven genomic discovery yields new insight into atrial fibrillation biology publication-title: Nat. Genet. doi: 10.1038/s41588-018-0171-3 – year: 2017 ident: CR52 article-title: Reference genes for gene expression studies in the mouse heart publication-title: Sci. Rep. doi: 10.1038/s41598-017-00043-9 – ident: CR65 – volume: 485 start-page: 376 year: 2012 end-page: 380 ident: CR29 article-title: Topological domains in mammalian genomes identified by analysis of chromatin interactions publication-title: Nature doi: 10.1038/nature11082 – ident: CR38 – volume: 41 start-page: 876 year: 2009 end-page: 878 ident: CR8 article-title: A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke publication-title: Nat. Genet. doi: 10.1038/ng.417 – year: 2014 ident: CR74 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 337 start-page: 1190 year: 2012 end-page: 1195 ident: CR19 article-title: Systematic localization of common disease-associate variation in regulatory DNA publication-title: Science doi: 10.1126/science.1222794 – ident: CR76 – ident: CR62 – year: 2009 ident: CR79 article-title: Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp045 – ident: CR24 – volume: 49 start-page: 946 year: 2017 end-page: 952 ident: CR16 article-title: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation publication-title: Nat. Genet. doi: 10.1038/ng.3843 – ident: CR20 – year: 2013 ident: CR73 article-title: STAR: Ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – year: 2016 ident: 12721_CR49 publication-title: Biochimica et. Biophysica Acta—Mol. Cell Res. doi: 10.1016/j.bbamcr.2015.11.025 – volume: 502 start-page: 499 year: 2013 ident: 12721_CR28 publication-title: Nature doi: 10.1038/nature12753 – year: 2003 ident: 12721_CR55 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1151 – volume: 109 start-page: 493 year: 2016 ident: 12721_CR13 publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvv283 – volume: 149 start-page: 1233 year: 2012 ident: 12721_CR27 publication-title: Cell doi: 10.1016/j.cell.2012.03.051 – ident: 12721_CR66 doi: 10.1128/MCB.00728-07 – volume: 122 start-page: 2519 year: 2012 ident: 12721_CR25 publication-title: J. Clin. Invest. doi: 10.1172/JCI62613 – ident: 12721_CR12 – volume: 102 start-page: 103 year: 2018 ident: 12721_CR11 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2017.12.003 – ident: 12721_CR47 doi: 10.1155/2015/798768 – volume: 130 start-page: 2071 year: 2014 ident: 12721_CR2 publication-title: Circulation doi: 10.1161/CIR.0000000000000040 – year: 2009 ident: 12721_CR79 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp045 – year: 2012 ident: 12721_CR68 publication-title: Circ. Arrhythmia Electrophysiol. doi: 10.1161/CIRCEP.111.966580 – ident: 12721_CR65 doi: 10.1007/s00210-009-0474-0.Cardiac – volume: 448 start-page: 353 year: 2007 ident: 12721_CR4 publication-title: Nature doi: 10.1038/nature06007 – volume: 30 start-page: 1411 year: 2010 ident: 12721_CR23 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01384-09 – ident: 12721_CR24 doi: 10.1371/journal.pgen.1003750 – volume: 94 start-page: 828 year: 2004 ident: 12721_CR53 publication-title: Circ. Res. doi: 10.1161/01.RES.0000122382.19400.14 – volume: 130 start-page: 1225 year: 2014 ident: 12721_CR14 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.114.009892 – ident: 12721_CR33 doi: 10.1016/j.cell.2016.09.018 – volume: 102 start-page: 717 year: 2018 ident: 12721_CR61 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2018.04.002 – volume: 35 start-page: 88 year: 2007 ident: 12721_CR59 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl822 – year: 2017 ident: 12721_CR52 publication-title: Sci. Rep. doi: 10.1038/s41598-017-00043-9 – volume: 62 start-page: 309 year: 2004 ident: 12721_CR54 publication-title: Cardiovasc. Res. doi: 10.1016/j.cardiores.2003.11.035 – ident: 12721_CR64 doi: 10.1371/journal.pgen.1002824 – volume: 114 start-page: 1483 year: 2014 ident: 12721_CR48 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.114.302226 – year: 2010 ident: 12721_CR77 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq319 – volume: 49 start-page: 953 year: 2017 ident: 12721_CR10 publication-title: Nat. Genet. doi: 10.1038/ng.3842 – ident: 12721_CR57 doi: 10.1016/j.cell.2015.06.060 – volume: 20 start-page: 1191 year: 2010 ident: 12721_CR18 publication-title: Genome Res. doi: 10.1101/gr.105361.110 – volume: 337 start-page: 1190 year: 2012 ident: 12721_CR19 publication-title: Science doi: 10.1126/science.1222794 – year: 2014 ident: 12721_CR74 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 49 start-page: 946 year: 2017 ident: 12721_CR16 publication-title: Nat. Genet. doi: 10.1038/ng.3843 – ident: 12721_CR72 doi: 10.3791/4205 – ident: 12721_CR26 doi: 10.1172/JCI73140 – ident: 12721_CR37 doi: 10.1038/s41467-018-07399-0 – volume: 159 start-page: 1665 year: 2014 ident: 12721_CR42 publication-title: Cell doi: 10.1016/j.cell.2014.11.021 – year: 2009 ident: 12721_CR75 publication-title: Nat. Protoc. doi: 10.1038/nprot.2008.211 – volume: 7 start-page: 1 year: 2016 ident: 12721_CR3 publication-title: Nat. Commun. doi: 10.1038/ncomms10190 – volume: 49 start-page: 946 year: 2017 ident: 12721_CR9 publication-title: Nat. Genet. doi: 10.1038/ng.3843 – year: 2018 ident: 12721_CR17 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0171-3 – volume: 47 start-page: 598 year: 2015 ident: 12721_CR41 publication-title: Nat. Genet. doi: 10.1038/ng.3286 – ident: 12721_CR69 doi: 10.1016/j.devcel.2013.04.017 – ident: 12721_CR45 doi: 10.1371/journal.pone.0026389 – ident: 12721_CR76 doi: 10.1016/j.molcel.2010.05.004 – ident: 12721_CR36 doi: 10.7554/eLife.35788 – ident: 12721_CR20 doi: 10.1371/journal.pgen.1003652 – volume: 339 start-page: 819 year: 2013 ident: 12721_CR78 publication-title: Science doi: 10.1126/science.1232033 – ident: 12721_CR35 doi: 10.1016/j.cell.2019.01.020 – volume: 5 start-page: 327 year: 2012 ident: 12721_CR44 publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.111.961631 – ident: 12721_CR67 doi: 10.1242/jcs.143743 – volume: 85 start-page: 207 year: 2015 ident: 12721_CR15 publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2015.06.005 – volume: 117 start-page: 413 year: 2015 ident: 12721_CR50 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.115.306337 – volume: 46 start-page: 136 year: 2014 ident: 12721_CR21 publication-title: Nat. Genet. doi: 10.1038/ng.2870 – year: 2016 ident: 12721_CR39 publication-title: Eur. J. Hum. Genet. doi: 10.1038/ejhg.2015.269 – volume: 46 start-page: 826 year: 2014 ident: 12721_CR63 publication-title: Nat. Genet. doi: 10.1038/ng.3014 – volume: 276 start-page: 25057 year: 2001 ident: 12721_CR56 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010378200 – volume: 42 start-page: 240 year: 2010 ident: 12721_CR5 publication-title: Nat. Genet. doi: 10.1038/ng.537 – ident: 12721_CR38 doi: 10.1093/nar/gkv1144 – ident: 12721_CR70 doi: 10.1016/j.cell.2016.01.004 – year: 2018 ident: 12721_CR58 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bty141 – year: 2014 ident: 12721_CR7 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2013.12.015 – year: 2018 ident: 12721_CR34 publication-title: Science doi: 10.1126/science.aau0320 – volume: 485 start-page: 376 year: 2012 ident: 12721_CR29 publication-title: Nature doi: 10.1038/nature11082 – year: 2013 ident: 12721_CR73 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 44 start-page: 1191 year: 2012 ident: 12721_CR22 publication-title: Nat. Genet. doi: 10.1038/ng.2416 – volume: 148 start-page: 458 year: 2012 ident: 12721_CR30 publication-title: Cell doi: 10.1016/j.cell.2012.01.010 – volume: 5 start-page: 1 year: 2016 ident: 12721_CR40 publication-title: eLife – volume: 129 start-page: 837 year: 2014 ident: 12721_CR1 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.005119 – ident: 12721_CR71 doi: 10.1016/j.cell.2016.07.012 – ident: 12721_CR51 doi: 10.1371/journal.pone.0092903 – volume: 485 start-page: 381 year: 2012 ident: 12721_CR31 publication-title: Nature doi: 10.1038/nature11049 – volume: 44 start-page: 670 year: 2012 ident: 12721_CR6 publication-title: Nat. Genet. doi: 10.1038/ng.2261 – volume: 17 start-page: 771 year: 2016 ident: 12721_CR32 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2016.138 – year: 2003 ident: 12721_CR43 publication-title: Circulation doi: 10.1161/01.CIR.0000074206.52056.2D – volume: 11 start-page: 266 year: 2014 ident: 12721_CR46 publication-title: Heart Rhythm. doi: 10.1016/j.hrthm.2013.10.051 – ident: 12721_CR60 doi: 10.1093/cvr/cvy134 – ident: 12721_CR62 doi: 10.1038/jhg.2015.44 – volume: 41 start-page: 876 year: 2009 ident: 12721_CR8 publication-title: Nat. Genet. doi: 10.1038/ng.417 – reference: 32623450 - Cardiovasc Res. 2020 Jul 15;116(9):e106-e108. doi: 10.1093/cvr/cvaa166 |
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| Snippet | Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of... The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and... |
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| SubjectTerms | 38 38/91 631/208/200 631/208/4041 631/337/100 631/337/572/2102 64 64/60 692/4019/592/75 Animals Atrial Fibrillation Atrial Fibrillation - genetics Cardiac arrhythmia Cardiomyocytes Cell Line Chromatin Chromatin - genetics Conformation Connexin 43 Epigenomics Epigenomics - methods Fibrillation Gap junctions Gene expression Gene Expression Profiling Gene Expression Profiling - methods Gene regulation Genes Genetic diversity Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic variance Genetic Variation Genome-wide association studies Genome-Wide Association Study Genome-Wide Association Study - methods Genomes Heart Atria Heart Atria - cytology Heart Atria - metabolism Homology Humanities and Social Sciences Humans Mice multidisciplinary Myocytes, Cardiac Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Polymorphism, Single Nucleotide Q Regulatory sequences Regulatory Sequences, Nucleic Acid Regulatory Sequences, Nucleic Acid - genetics Science Science (multidisciplinary) Transcription |
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| Title | Identification of atrial fibrillation associated genes and functional non-coding variants |
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