MiRNAs of peripheral blood as the biomarker of schizophrenia

The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contempor...

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Veröffentlicht in:Hereditas Jg. 155; H. 1; S. 9
Hauptverfasser: He, Kuanjun, Guo, Chuang, He, Lin, Shi, Yongyong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 29.08.2017
Nature Publishing Group
BMC
Schlagworte:
Animal Genetics and Genomics
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
blood
Epigenetics
Evolutionary Biology
Gene expression
Humans
Life Sciences
Mental disorders
microRNA
MicroRNAs
MicroRNAs - blood
Nervous system
Pathogenesis
patients
Peripheral blood
Peripheral MiRNAs
Physiology
Proteins
Psychiatry
Review
Schizophrenia
Schizophrenia - blood
Schizophrenia - diagnosis
Signal transduction
Significance and values
Studies
therapeutics
Schizophrenia
Biomarkers
Significance and values
Peripheral MiRNAs
ISSN:1601-5223, 0018-0661, 1601-5223
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the physiological, physical and biochemical status of the body, and so have extensive applicability and practical significance. The ascertainment of schizophrenia biomarkers will help diagnose, stratify of disease, and treat of schizophrenia patients. The detection of biomarkers from blood has become a promising area of schizophrenia research. Recently, a series of studies revealed that, MiRNAs play an important role in the genesis of schizophrenia, and their abnormal expressions have the potential to be used as biomarkers of schizophrenia. This article presents and summarizes the value of peripheral blood miRNAs with abnormal expression as the biomarker of schizophrenia.
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ISSN:1601-5223
0018-0661
1601-5223
DOI:10.1186/s41065-017-0044-2