Genetic variants of calcium and vitamin D metabolism in kidney stone disease

Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a heritability of ~45–60%. We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 cases and 417,378 controls, and identify 20 nephro...

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Vydáno v:	Nature communications Ročník 10; číslo 1; s. 5175 - 10
Hlavní autoři:	Howles, Sarah A., Wiberg, Akira, Goldsworthy, Michelle, Bayliss, Asha L., Gluck, Anna K., Ng, Michael, Grout, Emily, Tanikawa, Chizu, Kamatani, Yoichiro, Terao, Chikashi, Takahashi, Atsushi, Kubo, Michiaki, Matsuda, Koichi, Thakker, Rajesh V., Turney, Benjamin W., Furniss, Dominic
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 15.11.2019 Nature Publishing Group Nature Portfolio
Témata:	13/95 45 631/208/205/2138 631/443/810 631/80/86/1999 692/4022/1585/273 Adult Aged Asian People - genetics Calciferol Calcium Calcium (blood) Calcium (urinary) Calcium - metabolism Calcium ions Calcium oxalate Calcium signalling Calcium-sensing receptors Calculi Diacylglycerol Kinase - genetics Diacylglycerol Kinase - metabolism Dietary supplements Excretion Female Genetic diversity Genetic variance Genetic Variation Genome-wide association studies Genome-Wide Association Study Genomes Genotype Genotypes Heritability Humanities and Social Sciences Humans Japan Kidney Calculi - genetics Kidney Calculi - metabolism Kidney stones Kidneys Loci Male Metabolism Middle Aged multidisciplinary Nephrolithiasis Oxalic acid Patients Polymorphism, Single Nucleotide Precision medicine Prospective Studies Proteins - genetics Proteins - metabolism Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism Science Signal transduction Signaling Supplements United Kingdom Vitamin D Vitamin D - metabolism White People - genetics United Kingdom Japan
ISSN:	2041-1723, 2041-1723
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