Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

Background Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), as the first metastatic site, is also the first site where BrC-induced suppression of immune effector subsets occurs. Since intricate knowled...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 7; no. 1; pp. 133 - 14
Main Authors:	van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., van de Ven, Rieneke, te Velde, Elisabeth A., Rutgers, Emiel J. Th, van den Tol, Petrousjka M., Stockmann, Hein B.A.C., de Gruijl, Tanja D.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.05.2019 BioMed Central Ltd BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Adjuvant chemotherapy Antigens Breast cancer Cancer Cancer metastasis Cancer treatment Care and treatment Chemotherapy Clinical/Translational Cancer Immunotherapy Dendritic cell Dendritic cells Flow cytometry Genetic aspects Hormones Hospitals Immune suppression Immunology Immunotherapy Lymphatic system Lymphocytes Mastectomy Medical prognosis Medical research Medicine Medicine & Public Health Metastasis Oncology Pathology Research Article Sentinel lymph node Surgery T cells Tumor-infiltrating lymphocytes Tumors Immune suppression Dendritic cell Breast cancer Sentinel lymph node
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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