miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment

Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially regulated in individuals who will end up showing beneficial responses to antidepressant treatment compared to those who will not respond. Majo...

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Veröffentlicht in:	Nature medicine Jg. 20; H. 7; S. 764 - 768
Hauptverfasser:	Lopez, Juan Pablo, Lim, Raymond, Cruceanu, Cristiana, Crapper, Liam, Fasano, Caroline, Labonte, Benoit, Maussion, Gilles, Yang, Jennie P, Yerko, Volodymyr, Vigneault, Erika, El Mestikawy, Salah, Mechawar, Naguib, Pavlidis, Paul, Turecki, Gustavo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2014 Nature Publishing Group
Schlagworte:	14/63 38/39 38/61 38/88 38/90 631/337/384/331 692/53/2423 692/699/476/1414 82/51 82/80 Antidepressants Antidepressive Agents - therapeutic use Biomedicine Brain Brain - metabolism Cancer Research Cell Line Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Development and progression Drug therapy Economics Genetic aspects Health aspects Humans Infectious Diseases letter Major depressive disorder Mental depression Mental disorders Metabolic Diseases MicroRNA MicroRNAs - metabolism MicroRNAs - physiology Molecular Medicine Neurosciences Physiological aspects Primates Ribonucleic acid RNA Canada
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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Abstract	Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially regulated in individuals who will end up showing beneficial responses to antidepressant treatment compared to those who will not respond. Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns 1 . Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America 2 , 3 . Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families 4 . Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression 5 , 6 , 7 . Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 ( GRM4 ) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments.
AbstractList	Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially regulated in individuals who will end up showing beneficial responses to antidepressant treatment compared to those who will not respond. Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns 1 . Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America 2 , 3 . Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families 4 . Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression 5 , 6 , 7 . Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 ( GRM4 ) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments. Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially regulated in individuals who will end up showing beneficial responses to antidepressant treatment compared to those who will not respond. Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially regulated in individuals who will end up showing beneficial responses to antidepressant treatment compared to those who will not respond. Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns.sup.1. Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America.sup.2,3. Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families.sup.4. Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression.sup.5,6,7. Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments. Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns. Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America. Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families. Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression. Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments. Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns. Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America. Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families. Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression. Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments.Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns. Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America. Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families. Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switches of gene expression. Here we report on complementary studies using postmortem human brain samples, cellular assays and samples from clinical trials of patients with depression and show that miR-1202, a miRNA specific to primates and enriched in the human brain, is differentially expressed in individuals with depression. Additionally, miR-1202 regulates expression of the gene encoding metabotropic glutamate receptor-4 (GRM4) and predicts antidepressant response at baseline. These results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments.
Audience	Academic
Author	Yerko, Volodymyr Crapper, Liam Labonte, Benoit Lim, Raymond Mechawar, Naguib Lopez, Juan Pablo Cruceanu, Cristiana El Mestikawy, Salah Fasano, Caroline Maussion, Gilles Pavlidis, Paul Yang, Jennie P Vigneault, Erika Turecki, Gustavo
Author_xml	– sequence: 1 givenname: Juan Pablo surname: Lopez fullname: Lopez, Juan Pablo organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 2 givenname: Raymond surname: Lim fullname: Lim, Raymond organization: Department of Psychiatry, University of British Columbia – sequence: 3 givenname: Cristiana surname: Cruceanu fullname: Cruceanu, Cristiana organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 4 givenname: Liam surname: Crapper fullname: Crapper, Liam organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 5 givenname: Caroline surname: Fasano fullname: Fasano, Caroline organization: Douglas Mental Health University Institute, McGill University – sequence: 6 givenname: Benoit surname: Labonte fullname: Labonte, Benoit organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 7 givenname: Gilles surname: Maussion fullname: Maussion, Gilles organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 8 givenname: Jennie P surname: Yang fullname: Yang, Jennie P organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 9 givenname: Volodymyr surname: Yerko fullname: Yerko, Volodymyr organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 10 givenname: Erika surname: Vigneault fullname: Vigneault, Erika organization: Douglas Mental Health University Institute, McGill University – sequence: 11 givenname: Salah surname: El Mestikawy fullname: El Mestikawy, Salah organization: Douglas Mental Health University Institute, McGill University – sequence: 12 givenname: Naguib surname: Mechawar fullname: Mechawar, Naguib organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 13 givenname: Paul orcidid: 0000-0002-0426-5028 surname: Pavlidis fullname: Pavlidis, Paul organization: Department of Psychiatry, University of British Columbia – sequence: 14 givenname: Gustavo surname: Turecki fullname: Turecki, Gustavo email: gustavo.turecki@mcgill.ca organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24908571$$D View this record in MEDLINE/PubMed
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ContentType	Journal Article
Copyright	Springer Nature America, Inc. 2014 COPYRIGHT 2014 Nature Publishing Group Copyright Nature Publishing Group Jul 2014
Copyright_xml	– notice: Springer Nature America, Inc. 2014 – notice: COPYRIGHT 2014 Nature Publishing Group – notice: Copyright Nature Publishing Group Jul 2014
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Snippet	Gustavo Turecki and colleagues report that miR-1202, a miRNA specific to primates, is decreased in individuals with depression and seems to be differentially... Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns. Treatment of MDD...
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SubjectTerms	14/63 38/39 38/61 38/88 38/90 631/337/384/331 692/53/2423 692/699/476/1414 82/51 82/80 Antidepressants Antidepressive Agents - therapeutic use Biomedicine Brain Brain - metabolism Cancer Research Cell Line Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Development and progression Drug therapy Economics Genetic aspects Health aspects Humans Infectious Diseases letter Major depressive disorder Mental depression Mental disorders Metabolic Diseases MicroRNA MicroRNAs - metabolism MicroRNAs - physiology Molecular Medicine Neurosciences Physiological aspects Primates Ribonucleic acid RNA
Title	miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment
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