Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas and their metastases, EpCAM serves as a prognostic marker, a therapeutic target, and an anchor molecule on circulating and di...

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Bibliographic Details
Published in:	Cancer and metastasis reviews Vol. 39; no. 3; pp. 969 - 987
Main Authors:	Gires, Olivier, Pan, Min, Schinke, Henrik, Canis, Martin, Baeuerle, Patrick A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.09.2020 Springer Springer Nature B.V
Subjects:	Animals Antigens Biomedical and Life Sciences Biomedicine Cancer Research CD44 antigen Cell adhesion & migration Cell adhesion molecules Cell migration Cell proliferation Colorectal cancer Colorectal carcinoma E-cadherin Epidermal growth factor Epidermal growth factor receptors Epithelial Cell Adhesion Molecule - biosynthesis Epithelial Cell Adhesion Molecule - metabolism Epithelial cells Epithelial-Mesenchymal Transition Health aspects Humans Intracellular Intracellular signalling Mesenchyme Metastases Metastasis Neoplasms - metabolism Neoplasms - pathology Non-Thematic Review Oncology Proteolysis Raf protein Stem cells Tumor cells Wnt protein Liquid biopsy Carcinoma Metastasis EpCAM Regulated intramembrane proteolysis Epithelial-to-mesenchymal transition
ISSN:	0167-7659, 1573-7233, 1573-7233
Online Access:	Get full text
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