Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions

Polymersomes, made up of amphiphilic block copolymers, are emerging as a powerful tool in drug delivery and synthetic biology due to their high stability, chemical versatility, and surface modifiability. The full potential of polymersomes, however, has been hindered by a lack of versatile methods fo...

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Vydané v:Nature communications Ročník 8; číslo 1; s. 1240 - 10
Hlavní autori: Wong, Chin Ken, Mason, Alexander F., Stenzel, Martina H., Thordarson, Pall
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.11.2017
Nature Publishing Group
Nature Portfolio
Predmet:
639/638/455/941
639/638/541/966
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Biology
Block copolymers
Control methods
Copolymers
Drug delivery
Drug delivery systems
Humanities and Social Sciences
Hydrophobicity
Membrane structure
Membrane structures
Morphology
multidisciplinary
Organic chemistry
Polymerization
Polymers
Science
Science (multidisciplinary)
Self-assembly
Shape control
Solvation
Solvents
Surface stability
Synthetic biology
ISSN:2041-1723, 2041-1723
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Shrnutí:Polymersomes, made up of amphiphilic block copolymers, are emerging as a powerful tool in drug delivery and synthetic biology due to their high stability, chemical versatility, and surface modifiability. The full potential of polymersomes, however, has been hindered by a lack of versatile methods for shape control. Here we show that a range of non-spherical polymersome morphologies with anisotropic membranes can be obtained by exploiting hydrophobic directional aromatic interactions between perylene polymer units within the membrane structure. By controlling the extent of solvation/desolvation of the aromatic side chains through changes in solvent quality, we demonstrate facile access to polymersomes that are either ellipsoidal or tubular-shaped. Our results indicate that perylene aromatic interactions have a great potential in the design of non-spherical polymersomes and other structurally complex self-assembled polymer structures. Polymersomes have become a powerful tool in drug delivery and synthetic biology, but their use can be restricted by a lack of versatile methods for shape control. Here the authors demonstrate access to a range of non-spherical polymersome morphologies by exploiting hydrophobic directional aromatic perylene interactions within the membrane structure.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-017-01372-z