Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth

Objective: Key appetite regulators and their receptors are already present in the fetal hypothalamus, and may respond to hormones such as leptin. Intrauterine food restriction or hyperglycemia can reprogram these circuits, possibly predisposing individuals to adverse health outcomes in adulthood. Gi...

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Bibliographic Details
Published in:	International Journal of Obesity Vol. 33; no. 1; pp. 115 - 122
Main Authors:	Morris, M.J, Chen, H
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.01.2009 Nature Publishing Group
Subjects:	Agouti-Related Protein Agouti-Related Protein - analysis Agouti-Related Protein - genetics analysis animal models Animals Animals, Newborn Animals, Newborn - metabolism appetite Appetite Regulation biochemical pathways Biological and medical sciences Biomarkers Biomarkers - analysis blood Body weight chemistry Diet Eating disorders Epidemics Epidemiology experimental diets Female fetal development genetics Health Promotion and Disease Prevention hormone secretion Hormones Hyperphagia hypothalamic regulation Hypothalamus Hypothalamus - chemistry Hypothalamus - metabolism Insulin Insulin - blood Internal Medicine Leptin Leptin - blood Male maternal nutrition Maternal Nutritional Physiological Phenomena Medical sciences Medicine Medicine & Public Health Metabolic Diseases metabolism Neuropeptide Y Neuropeptide Y - analysis Neuropeptide Y - genetics nutrition physiology Obesity Obesity - metabolism Offspring original-article Overnutrition overweight parturition Physiological aspects physiological regulation physiology Pregnancy Pro-Opiomelanocortin Pro-Opiomelanocortin - analysis Pro-Opiomelanocortin - genetics Public Health Rats Rats, Sprague-Dawley Receptors, Leptin Receptors, Leptin - analysis Risk factors RNA, Messenger RNA, Messenger - analysis Signal Transduction Signal Transduction - physiology STAT3 Transcription Factor STAT3 Transcription Factor - analysis STAT3 Transcription Factor - genetics weight gain Australia newborn maternal obesity leptin NPY programming Human Appetite Obesity Nutrition Rat Rodentia Nutrition disorder Programming Metabolic diseases Adipokine Regulator Birth Signal transduction Vertebrata Regulation(control) Mammalia Newborn Mother Animal Leptin Nutritional status
ISSN:	0307-0565, 1476-5497, 1476-5497
Online Access:	Get full text
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