High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries

A fundamental question in microbiology is whether there is continuum of genetic diversity among genomes, or clear species boundaries prevail instead. Whole-genome similarity metrics such as Average Nucleotide Identity (ANI) help address this question by facilitating high resolution taxonomic analysi...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 5114 - 8
Main Authors:	Jain, Chirag, Rodriguez-R, Luis M., Phillippy, Adam M., Konstantinidis, Konstantinos T., Aluru, Srinivas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.11.2018 Nature Publishing Group Nature Portfolio
Subjects:	45 631/114 631/326 Alignment Biodiversity Boundaries Databases, Factual Discontinuity Gene mapping Genetic diversity Genetic Variation - genetics Genome, Bacterial - genetics Genomes Humanities and Social Sciences Mapping Microbiology multidisciplinary Nucleotides Phylogeny Prokaryotic Cells - metabolism Questions Robustness Science Science (multidisciplinary) Sequence Analysis, DNA Species
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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