Ambient black carbon particles reach the fetal side of human placenta

Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond p...

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Vydané v:	Nature communications Ročník 10; číslo 1; s. 3866 - 7
Hlavní autori:	Bové, Hannelore, Bongaerts, Eva, Slenders, Eli, Bijnens, Esmée M., Saenen, Nelly D., Gyselaers, Wilfried, Van Eyken, Peter, Plusquin, Michelle, Roeffaers, Maarten B. J., Ameloot, Marcel, Nawrot, Tim S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 17.09.2019 Nature Publishing Group Nature Portfolio
Predmet:	14/19 14/28 14/69 631/443/494 639/925/928/833 692/700/478 Air Pollutants - metabolism Air Pollutants - toxicity Air pollution Belgium Biopsy Birth Black carbon Carbon Cohort Studies Ecotoxicology Exposure Female Fetuses Humanities and Social Sciences Humans Maternal Exposure - adverse effects Maternal-Fetal Exchange Microscopy, Electron, Transmission multidisciplinary Particle deposition Particulate matter Particulates Permeability Placenta Placenta - metabolism Placenta - pathology Placenta - ultrastructure Pollution effects Pregnancy Residence Characteristics - statistics & numerical data Science Science (multidisciplinary) Soot - analysis Soot - metabolism Soot - toxicity White light Belgium
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screened placentae, with an average (SD) particle count of 0.95 × 10 4 (0.66 × 10 4 ) and 2.09 × 10 4 (0.9 × 10 4 ) particles per mm 3 for low and high exposed mothers, respectively. Furthermore, the placental BC load is positively associated with mothers’ residential BC exposure during pregnancy (0.63–2.42 µg per m 3 ). Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life onwards. Exposure to air pollution during pregnancy has been associated with impaired birth outcomes. Here, Bové et al. report evidence of black carbon particle deposition on the fetal side of human placentae, including at early stages of pregnancy, suggesting air pollution could affect birth outcome through direct effects on the fetus.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-11654-3