An epigenome-wide association study of sex-specific chronological ageing

Background Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we investigat...

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Vydané v:	Genome medicine Ročník 12; číslo 1; s. 1 - 11
Hlavní autori:	McCartney, Daniel L., Zhang, Futao, Hillary, Robert F., Zhang, Qian, Stevenson, Anna J., Walker, Rosie M., Bermingham, Mairead L., Boutin, Thibaud, Morris, Stewart W., Campbell, Archie, Murray, Alison D., Whalley, Heather C., Porteous, David J., Hayward, Caroline, Evans, Kathryn L., Chandra, Tamir, Deary, Ian J., McIntosh, Andrew M., Yang, Jian, Visscher, Peter M., McRae, Allan F., Marioni, Riccardo E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 31.12.2019 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Adult Age Aged Ageing Aging Aging - genetics Analysis Bioinformatics Biomedical and Life Sciences Biomedicine Blood Cancer Research Chromosomes, Human, X - genetics Cognitive ability CpG Islands Deoxyribonucleic acid Disease DNA DNA Methylation Epigenetics Female Gene Expression Regulation Gene mapping Generation Scotland Genes Genome-Wide Association Study Genomes Genomics Health aspects Human Genetics Humans Life expectancy Life span Linear Models Male Medicine/Public Health Metabolomics Methylation Middle Aged Mortality Prostate cancer Quality control Quantitative Trait Loci Regression analysis Replication Risk factors Sex Sex Characteristics Sex differences Sexual dimorphism Software Studies Systems Biology X chromosome United Kingdom United Kingdom > UK Scotland DNA methylation Sexual dimorphism Generation Scotland Ageing X chromosome
ISSN:	1756-994X, 1756-994X
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