Engineered Endolysin-Based “Artilysins” To Combat Multidrug-Resistant Gram-Negative Pathogens

The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates the development of novel approaches to combat bacterial infections. Endolysins encoded by bacterial viruses (or phages) represent one promising avenue of investigation. These enzyme-b...

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Bibliographic Details
Published in:	mBio Vol. 5; no. 4; p. e01379
Main Authors:	Briers, Yves, Walmagh, Maarten, Van Puyenbroeck, Victor, Cornelissen, Anneleen, Cenens, William, Aertsen, Abram, Oliveira, Hugo, Azeredo, Joana, Verween, Gunther, Pirnay, Jean-Paul, Miller, Stefan, Volckaert, Guido, Lavigne, Rob
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01.07.2014 American Society of Microbiology
Subjects:	Acinetobacter baumannii Acinetobacter baumannii - drug effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics bacterial infections bacteriophages Caenorhabditis elegans Cell walls Drug resistance Drug Resistance, Multiple, Bacterial - drug effects E coli endolysin Endopeptidases - chemistry Gram-positive bacteria health services humans Hydrolysis Hydrophobicity Keratinocytes Lipopolysaccharides mechanism of action Microscopy Morbidity mortality Multidrug resistance multiple drug resistance Pathogens Peptides Peptidoglycans probability Protein engineering Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Public health Salmonella Standard deviation
ISSN:	2161-2129, 2150-7511, 2150-7511
Online Access:	Get full text
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