Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing interspecies differences in the transcriptional responses of primary human and mouse macrophages to the Toll-like...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 16; S. E944
Hauptverfasser:	Schroder, Kate, Irvine, Katharine M, Taylor, Martin S, Bokil, Nilesh J, Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I, Semple, Colin A, Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J, Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O, Kawaji, Hideya, McLachlan, Geoffrey J, Goldman, Nick, Grimmond, Sean M, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A, Sweet, Matthew J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.04.2012
Schlagworte:	Animals Cell Line Cells, Cultured Chemokine CCL20 - genetics Chemokine CXCL13 - genetics Evolution, Molecular Female Gene Expression Profiling Gene Expression Regulation - drug effects Genetic Variation Host-Pathogen Interactions Humans Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Macrophages - microbiology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Salmonella typhimurium - physiology Species Specificity Swine Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - genetics
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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