CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is associated with plasticity of nociceptive pathway in which pain is prolonged even after healing of the injured tissue. Generally combinations of analgesic drugs are not sufficient to achieve select...

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Bibliographic Details
Published in:Neurobiology of disease Vol. 105; pp. 109 - 116
Main Authors: Silva, Rangel L., Lopes, Alexandre H., Guimarães, Rafaela M., Cunha, Thiago M.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.09.2017
Elsevier
Subjects:
Animals
Central Nervous System Sensitization - physiology
Chemokine
Chemokine CXCL1 - metabolism
CXCL1
CXCR2
Humans
Inflammatory pain
Neurology
Neuropathic pain
Pain - etiology
Pain - metabolism
Pain - pathology
Peripheral Nerve Injuries - complications
Receptors, Interleukin-8B - metabolism
Signal Transduction - physiology
Chemokine
CXCL1
Inflammatory pain
CXCR2
Neuropathic pain
ISSN:0969-9961, 1095-953X, 1095-953X
Online Access:Get full text
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Summary:Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is associated with plasticity of nociceptive pathway in which pain is prolonged even after healing of the injured tissue. Generally combinations of analgesic drugs are not sufficient to achieve selective palliation from chronic pain, besides causing a greater number of side effects. In order to identify novel alternatives for more effective treatments, it is necessary to clarify the underlying mechanisms of pathological pain. It is well established that there are two main components in pathological pain development and maintenance: (i) primary sensory neuron sensitization (peripheral sensitization), and (ii) central sensitization. In both components cytokines and chemokines act as key mediators in pain modulation. CXCL1 is a chemokine that promote both nociceptor and central sensitization via its main receptor CXCR2, which is a promising target for novel analgesic drugs. Here, we reviewed and discussed the role of the CXCL1/CXCR2 signaling axis in pathological pain conditions triggered by either peripheral inflammation or nerve injury.
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ISSN:0969-9961
1095-953X
1095-953X
DOI:10.1016/j.nbd.2017.06.001