CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is associated with plasticity of nociceptive pathway in which pain is prolonged even after healing of the injured tissue. Generally combinations of analgesic drugs are not sufficient to achieve select...

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Bibliographic Details
Published in:	Neurobiology of disease Vol. 105; pp. 109 - 116
Main Authors:	Silva, Rangel L., Lopes, Alexandre H., Guimarães, Rafaela M., Cunha, Thiago M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2017 Elsevier
Subjects:	Animals Central Nervous System Sensitization - physiology Chemokine Chemokine CXCL1 - metabolism CXCL1 CXCR2 Humans Inflammatory pain Neurology Neuropathic pain Pain - etiology Pain - metabolism Pain - pathology Peripheral Nerve Injuries - complications Receptors, Interleukin-8B - metabolism Signal Transduction - physiology Chemokine CXCL1 Inflammatory pain CXCR2 Neuropathic pain
ISSN:	0969-9961, 1095-953X, 1095-953X
Online Access:	Get full text
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