Viral Load, Integration and Methylation of E2BS3 and 4 in Human Papilloma Virus (HPV) 16-Positive Vaginal and Vulvar Carcinomas

To investigate if viral load, integration and methylation of E2BS3 and 4 represent different ways of tumor transformation in vaginal and vulvar carcinoma and to elucidate its clinical impact. Fifty-seven samples, positive for HPV16, were selected for the study. Detection of viral load was made with...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 11; p. e112839
Main Authors:	Lillsunde Larsson, Gabriella, Helenius, Gisela, Sorbe, Bengt, Karlsson, Mats G.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2014 Public Library of Science (PLoS)
Subjects:	Antiretroviral drugs Biology and Life Sciences Biomarkers Carcinogenesis Carcinogens Carcinoma Cell cycle Cervical cancer Copy number Deoxyribonucleic acid DNA DNA methylation DNA, Viral - metabolism Female Gene expression Genital cancers Genomes Genotype & phenotype Hospitals Human papillomavirus Human papillomavirus 16 - metabolism Humans Integration Laboratories Medicine and Health Sciences Methylation Papillomavirus Infections - metabolism Papillomavirus Infections - mortality Papillomavirus Infections - pathology Pathogenesis Polymerase chain reaction Proteins Retrospective Studies Sampling methods Studies Survival Transformation Tumors Vagina Vaginal Neoplasms - metabolism Vaginal Neoplasms - mortality Vaginal Neoplasms - pathology Vaginal Neoplasms - virology Viral Load Virus Integration Viruses Vulvar Neoplasms - metabolism Vulvar Neoplasms - mortality Vulvar Neoplasms - pathology Vulvar Neoplasms - virology Sweden
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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