Random Migration and Signal Integration Promote Rapid and Robust T Cell Recruitment

To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search within each LN. Here we combine simulations and exper...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PLoS computational biology Ročník 10; číslo 8; s. e1003752
Hlavní autoři:	Textor, Johannes, Henrickson, Sarah E., Mandl, Judith N., von Andrian, Ulrich H., Westermann, Jürgen, de Boer, Rob J., Beltman, Joost B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 01.08.2014 Public Library of Science (PLoS)
Témata:	Animals Biology and Life Sciences Cell adhesion & migration Cell Communication - immunology Cell migration Cell Movement - immunology Cell research Computational Biology Experiments Health aspects Humans Immune system Infection control Infections Lymph nodes Lymphocytes Mice Models, Immunological Monte Carlo simulation Random variables Retention Signal Transduction Surveillance T cells T-Lymphocytes - immunology Viral infections
ISSN:	1553-7358, 1553-734X, 1553-7358
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!