Allosteric mechanism of the circadian protein Vivid resolved through Markov state model and machine learning analysis

The fungal circadian clock photoreceptor Vivid (VVD) contains a photosensitive allosteric light, oxygen, voltage (LOV) domain that undergoes a large N-terminal conformational change. The mechanism by which a blue-light driven covalent bond formation leads to a global conformational change remains un...

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Veröffentlicht in:	PLoS computational biology Jg. 15; H. 2; S. e1006801
Hauptverfasser:	Zhou, Hongyu, Dong, Zheng, Verkhivker, Gennady, Zoltowski, Brian D., Tao, Peng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.02.2019 Public Library of Science (PLoS)
Schlagworte:	Algorithms Allosteric properties Allosteric proteins Artificial intelligence Biology and Life Sciences Chemical bonds Circadian rhythm Circadian rhythms Classification Computer and Information Sciences Computer applications Covalent bonds Gene expression Investigations Learning algorithms Light Linear algebra Machine learning Markov chains Mathematical models Neural networks Novels Observations Photosensitivity Physical Sciences Physiological aspects Protein binding Proteins Quantitative analysis Research and Analysis Methods United States > US Texas California
ISSN:	1553-7358, 1553-734X, 1553-7358
Online-Zugang:	Volltext
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