Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

The ability of Mycobacterium tuberculosis (Mtb) to thrive in its phagosomal niche is critical for its establishment of a chronic infection. This requires that Mtb senses and responds to intraphagosomal signals such as pH. We hypothesized that Mtb would respond to additional intraphagosomal factors t...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 9; no. 4; p. e1003282
Main Authors:	Tan, Shumin, Sukumar, Neelima, Abramovitch, Robert B., Parish, Tanya, Russell, David G.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2013 Public Library of Science (PLoS)
Subjects:	Acidification Animals Anions Bacterial Proteins - metabolism Biology Bone Marrow Cells Cells, Cultured Cellular Microenvironment - physiology Chlorides - pharmacology Chlorine Gene Expression Regulation, Bacterial Host-bacteria relationships Hydrogen-Ion Concentration Immune response Interferon-gamma - genetics Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Mycobacterium tuberculosis - physiology Observations Pathogenesis Phagosomes - metabolism Phagosomes - microbiology Promoter Regions, Genetic Properties Studies Testing Tuberculosis Tuberculosis - microbiology United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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