Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy

A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use as phenotypes concentrations of limited sets of metabolites that can be identified and quantified from spectral information. In contrast, in an untarget...

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Vydané v:	PLoS computational biology Ročník 13; číslo 12; s. e1005839
Hlavní autori:	Rueedi, Rico, Mallol, Roger, Raffler, Johannes, Lamparter, David, Friedrich, Nele, Vollenweider, Peter, Waeber, Gérard, Kastenmüller, Gabi, Kutalik, Zoltán, Bergmann, Sven
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.12.2017 Public Library of Science (PLoS)
Predmet:	Bioinformatics Biology Biology and Life Sciences Databases, Genetic Environmental health Funding Genetic aspects Genetic diversity Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Hospitals Humans Identification Identification and classification Internal medicine Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Medicine and Health Sciences Metabolism Metabolites Metabolomics Metabolomics - methods Methods NMR NMR spectroscopy Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Physical Sciences Preventive medicine Research and analysis methods Ships Software Studies Supervision Urine Wavelet transforms
ISSN:	1553-7358, 1553-734X, 1553-7358
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