Direct coupling analysis of epistasis in allosteric materials

In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable interest in inferring them from sequence alignment data. Currently, different methods lead to conflicting results, in pa...

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Vydané v:	PLoS computational biology Ročník 16; číslo 3; s. e1007630
Hlavní autori:	Bravi, Barbara, Ravasio, Riccardo, Brito, Carolina, Wyart, Matthieu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.03.2020 Public Library of Science (PLoS)
Predmet:	Allosteric properties Analysis Biology and Life Sciences Cost analysis Couplings Drug development Empirical analysis Epistasis Evolution Gene mutation Generic drugs Ligands Medicine and Health Sciences Mutation Nucleotide sequence Physics Protein binding Proteins Research and Analysis Methods Software Iran Switzerland
ISSN:	1553-7358, 1553-734X, 1553-7358
On-line prístup:	Získať plný text
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