Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers

Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-derived epoxyeicosatrienoic acid (EET)-mediated endothelial function is impaired in patients with COPD and that a novel soluble epoxide hy...

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Bibliographic Details
Published in:	Chest Vol. 151; no. 3; pp. 555 - 563
Main Authors:	Yang, Lucy, Cheriyan, Joseph, Gutterman, David D, Mayer, Ruth J, Ament, Zsuzsanna, Griffin, Jules L, Lazaar, Aili L, Newby, David E, Tal-Singer, Ruth, Wilkinson, Ian B
Format:	Journal Article
Language:	English
Published:	United States 01.03.2017
Subjects:	8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism Adult Aged Blood Vessels - drug effects Blood Vessels - physiopathology Bradykinin - pharmacology Case-Control Studies Cyclohexylamines - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Epoxide Hydrolases - antagonists & inhibitors Fluconazole - pharmacology Forearm - blood supply Humans In Vitro Techniques Male Middle Aged Overweight - metabolism Overweight - physiopathology Plethysmography Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Smoking - metabolism Smoking - physiopathology Triazines - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology clinical trial endothelial function soluble epoxide hydrolase inhibitor smokers COPD EETs
ISSN:	1931-3543
Online Access:	Get more information
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